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The authors propose a model for the mechanism underlying how a phage defence system remains primed for infection but tightly controlled to prevent host toxicity.
A membrane- and DNA-targeting approach is used to design a compound that displays potent activity against multidrug-resistant fungal pathogens without inducing antifungal resistance.
Longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period shows that microbes acquired from cow microbiomes introduce clinically relevant antimicrobial resistance genes to farmer guts.
Prophage-encoded anti-phage defence systems in Staphylococcus aureus protect hosts from superinfection but also prevent autoimmunity via an overlapping gene.
Virological, clinical and immunological characterization of a dengue virus 3 human challenge model could help with identifying vaccine and drug candidates.
GvpU regulates spatial organization of gas vesicles in the bacterial cytosol through tunable interactions with the core gas vesicle shell protein and phase transition, enabling future opportunities for engineering of cellular buoyancy.
Exposing cerebral organoids and post-mortem brain explants to SARS-CoV-2 virus particles alters expression of synaptic proteins and potentially affects synaptic function by blocking LPHN3 and FLRT3 synapses.
Laboratory and clinical strains of Crimean–Congo haemorrhagic fever virus use LDLR to bind and enter host cells in blood vessel organoids and mice. Infection can also occur through ApoE, possibly present on virus particles.
Cryo-EM analysis of the substrate-bound T9SS from Flavobacterium johnsoniae reveals an extended translocon complex and provides insight into protein secretion.
The FEAR pathway acts via FACT and ETS-1 and elicits antiviral responses against various DNA and RNA viruses independent of interferons, which are countered by poxvirus A51R proteins.
Phosphatidylserine-exposing extracellular vesicles in body fluids can inhibit infection of viruses that use viral apoptotic mimicry for infection, but not viruses that use other entry mechanisms.
Toll-interacting protein (TOLLIP) prevents inflammation and lipid accumulation in alveolar macrophages to limit integrated stress response activation, macrophage necrosis and promote control of Mycobacterium tuberculosis.
Phylogenetic analysis of halophilic archaea, including two previously undescribed clades, reveals four independent evolutionary adaptations to hypersaline environments, caused by duplications and horizontal gene transfers.
Prevotella copri, together with other microbiota members, plays a key role in mediating the beneficial effects of a gut microbiota-directed complementary food for malnourished children on microbiota and host functions.
Testing 255 combinations of chemicals versus bacterial communities shows species diversity contributes to resilience against increasingly complex stressor mixtures.
Cryogenic electron microscopy analysis of the Mycobacterium tuberculosis membrane-bound phosphoribosyltransferase Rv3806c provides mechanistic insight into cell wall precursor synthesis.
Single-molecule imaging reveals that peptidoglycan synthesis and synthase activity, rather than FtsZ treadmilling, are rate limiting and drive septum constriction in Staphylococcus aureus.
Live-cell single-molecule imaging reveals a single population of processive septal peptidoglycan synthases moving asynchronously with FtsZ that drive Bacillus subtilis cell constriction in a manner partially dependent upon FtsZ treadmilling.