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The 2014 Nobel Prize in Chemistry has been awarded in recognition of super-resolution fluorescence microscopy. To fully realize the tremendous promise of these methods for biological discovery, there are still challenges to be overcome.
Tissue samples scatter light and shut out a deeper gaze. Tissue-clearing agents have changed that, but scientists must consider optimizing the optics when using these methods.
The idea of using hybrid proteins containing transcription factor domains to analyze protein-protein interactions was described in 1989. Over the past 25 years, this method has begun to reveal the complex protein networks that underlie cellular behavior.
Imaging of electrical activity in vivo in Caenorhabditis elegans is possible with the improved genetically encoded voltage sensors Archer1 and Archer2.