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RNA-based therapeutics hold promise for the treatment of several diseases. This Review provides an overview of hydrogels for RNA delivery, discussing how the chemical nature and physical properties of hydrogels can be explored for tailored RNA loading and release, and highlighting the use of these materials in biomedical applications.
A bioengineered model incorporating a synthetic extracellular matrix recapitulates the lymphoid tumour microenvironment, making it a valuable tool for drug testing and designing personalized therapies.
Time-dependent pump–probe studies of polaritonic transport — for polaritons formed by strong coupling between organic molecules and Bloch surface waves at the interface of a distributed Bragg reflector — reveal a transition between diffusive and ballistic behaviour.
A large-scale screening identifies an inhalable polymer nanoparticle formulation that safely and effectively delivers therapeutic mRNA molecules to the lungs of several animal species.
Targeting P-selectin enables safer and more effective nanomedicine delivery through caveolin-1-mediated endothelial transcytosis in preclinical medulloblastoma tumour models.
By exploiting optical phase-modulation at complex surface plasmon polariton patterns, as well as energy-filtered imaging, femtosecond electron pulses are dynamically shaped in phase and amplitude.
Persistent luminescent phosphors are promising for applications from bioimaging to multilevel encryption. Here, the authors review the design and preparation of persistent luminescence nanomaterials, developments in biological applications and outstanding challenges.
When BiFeO3 layers are confined between TbScO3 layers in an epitaxial superlattice, crystallographically orthogonal voltages can induce reversible, non-volatile switching between polar and antipolar states in BiFeO3. This symmetry switch also leads to marked changes in the nonlinear optical response, piezoresponse and resistivity of the system.
Soft actuators composed of a tough bioadhesive/elastomer shell encapsulating a stimuli-responsive metallic spring provide in situ mechanical stimulation of skeletal muscles to promote muscle tissue rehabilitation and prevent atrophy.
Two studies explore strongly correlated states of Bose–Fermi excitonic complexes realized in two distinct solid-state platforms, setting the stage for tabletop quantum simulators.
Colloidal nanocrystals can form into periodic superlattices exhibiting collective vibrations from the correlated motion of the nanocrystals. This Perspective discusses such collective vibrations and their as-of-yet untapped potential applications for phononic crystals, acoustic metamaterials and optomechanical systems.
Research on two-dimensional van der Waals ferroelectrics has witnessed an explosion over the past few years. This Perspective formulates a framework by which results can be analysed, reviews recent progress, discusses mechanisms and properties for applications, and outlines challenges to be addressed.
A new spectroscopic technique takes advantage of overlapping electronic bands to probe the strongly correlated states of magic-angle twisted trilayer graphene.
Transforming atomically thin materials by their magnetic neighbours reveals a surprising asymmetry that allows a versatile control of the valley degrees of freedom and band topology in van der Waals heterostructures.
