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Cohort-scale integration of clinical and proteomic data from tumor tissues in patients with pancreatic ductal adenocarcinoma led to the identification of a prognostic risk model for patient stratification as well as biomarkers of response to adjuvant chemotherapy, validated in independent external cohorts.
Simulation of improvements in hypertension care across wealth quintiles in 44 low- and middle-income countries demonstrates that targeted improvements in diagnosis and treatment could considerably reduce within-country, socioeconomic-based inequalites in cardiovascular disease burden.
This study identifies a fluid biomarker of TDP-43 dysfunction, a central pathological feature of the ALS–FTD disease spectrum, and demonstrates that such loss of TDP-43 splicing repression occurs presymptomatically.
In patients with resected, high-risk melanoma, the addition of a personalized mRNA-based neoantigen therapy to adjuvant pembrolizumab was more effective than pembrolizumab alone.
Profiling of a case of secondary T cell lymphoma following anti-CD19 CAR T cell therapy suggests that it was not caused by CAR insertional mutagenesis, with single-center analysis indicating that secondary T cell lymphoma risk after commercial CAR T cell treatment is low.
Implementation of multifactorial interventions in a low- to middle-income setting during preconception, pregnancy and early childhood resulted in improvements to child neurodevelopment at 24 months of age.
In a large prospective cohort of 1,090 pregnant women with a high risk of fetal genetic diseases, a cell-free DNA screening identified cases of aneuploidies, microdeletions and monogenic variants with high accuracy in concordance to standard diagnostic tests
We are launching a new Series as a starting point for discussions on how to improve the health of women and girls as part of a route to achieving global health equity.
High financial costs and limited evidence restrict the adoption of robotic surgery, but new uses for robots and attempts to assess efficacy could widen access.
To guide the safe implementation of the next generation of surgical robots, the IDEAL Robotics Colloquium provides recommendations for their evaluation throughout the product life cycle—considering multiple perspectives within and beyond the surgical team.
The unique risks and needs of women in relation to noncommunicable diseases offer myriad opportunities to intervene and prevent disease, but several key barriers to implementation must be addressed.
Results from a multicenter, randomized phase 2 trial in China show that adjuvant anti-PD-1 therapy in patients with resected hepatocellular carcinoma with microvascular invasion leads to prolonged recurrence-free survival compared to active surveillance.
Researchers used machine-learning models to emulate thousands of clinical trials from over 10 years’ worth of real-world data, generating a shortlist of five candidate drugs for repurposing.
Known as tethered macrocyclic peptides, a new class of antibiotics show potent activity against drug-resistant strains of Acinetobacter baumannii — with one candidate already in clinical trials.