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Volume 8 Issue 9, September 2007

Whether CD8+ T cells, like CD4+ T cells, provide 'help' to other T cells is not clear. Amigorena and colleagues demonstrate that antigen-specific CD8+ T cells 'help' naive CD8+ T cells by promoting the interaction of naive CD8+ T cells with antigen-bearing dendritic cells. The original time-lapse video image shows antigen-specific CD8+ T cells (red) interacting with antigen-bearing dendritic cells (gray). Naive CD8+ T cells are shown in green. Artwork by Lewis Long.

Volume 8 Issue 9

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  • Scientific exchange and knowledge is not bound by international boundaries; indeed, science can promote interaction and understanding across such boundaries.

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  • A new subset of interleukin 17–producing CD4+ helper T cells with diverse functions has now been identified. New work by three groups substantially broadens the understanding of these cells in both mice and humans.

    • Arian Laurence
    • John J O'Shea
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  • Studies of genetically modified reporter mice have provided insight into the development of regulatory T cells. New work shows that regulatory T cells producing interleukin 10 arise in the periphery from Foxp3+ and Foxp3− thymic progenitors.

    • Paulo Vieira
    • Anne O'Garra
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  • A new study in Nature identifies a long-sought cytoplasmic 'sensor' that is responsible, at least in part, for interferon responses induced by double-stranded DNA.

    • Mitsutoshi Yoneyama
    • Takashi Fujita
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  • Specialized macrophage-like cells initiate antibody responses by trapping antigen in lymph. These antigen-trapping cells are located in the migration pathway of recirculating B cells, which can engage the trapped antigen.

    • Ian MacLennan
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