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The biological role of 2′-O-methylation of host and viral mRNA has remained elusive. Thiel and co-workers show that this modification modulates the induction of type I interferon and sensitivity to interferon.
TH2 cells are important for allergic and antiparasitic responses. Sun and colleagues demonstrate highly selective expression of the ECM1 protein in TH2 cells and a key role for it in regulating migration.
The function of the chemokine CCL8 has remained unknown. Luster and colleagues show that CCL8 has high expression in allergic skin, where it recruits CCR8+ TH2 cells with abundant IL-5 expression.