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Jack Strominger recounts his seminal work and contributions to understanding bacterial cell wall components, and thus how penicillin functions, and the implications of these discoveries for immunology.
Tremendous effort to understand how microbes influence health has brought fewer advances in treating and preventing disease than one might have expected.
Andrew McMichael recounts the seminal data he and colleagues produced demonstrating that cytotoxic T lymphocytes kill cells expressing antigenic peptides presented on major histocompatibility complex class I molecules.
We will never have a better opportunity to improve public health globally. The question is whether we are shrewd enough, bold enough, and committed enough to make it happen.
As part of the Global Theme Issue on Poverty and Human Development, Frances Gotch and Jill Gilmour describe the development of laboratory capacity to support HIV vaccine trials as a model for technology transfer in the developing world.
Relatively few studies have used live tissue microscopy to evaluate how the immune system responds to pathogens. In this commentary we discuss the challenges of imaging infectious processes and the questions that can be addressed with these dynamic approaches.
The year 2007 marks the 50th anniversary of the publication of Burnet's clonal selection theory. This theory provided an intellectual framework that revolutionized the field of immunology.
This year marks the 50th anniversary of Burnet's clonal selection theory. Here Gustav Nossal recounts his pioneering work that supported Burnet's theory and led to the death of the direct template hypothesis.
October 2007 marks the 50th anniversary of the publication of Frank Macfarlane Burnet's clonal selection theory in the Australian Journal of Science. This short article, republished at the end of this commentary, revolutionized the field of immunology.
Scientific exchange and knowledge is not bound by international boundaries; indeed, science can promote interaction and understanding across such boundaries.