Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Lymphocyte development is regulated by Ikaros transcription factors. Georgopoulos and colleagues show that Ikaros tethers the nucleosome-remodeling factor Mi-2β and restrains its ability to act at nonlymphoid gene sites.
Induced regulatory T cells are important for peripheral tolerance. Oliver and colleagues identify a key function for the adaptor Ndfip1 in stabilizing the identity and function of such cells.
Id proteins negatively regulate the binding of E-protein transcription factors to DNA. Goldrath et al. show that Id2 and Id3 are important in the generation of memory in distinct functional populations of CD8+ cells.
The molecular basis of CD8+ memory is still being delineated. Gattinoni et al. show that the DNA-binding inhibitor Id3 is critical for the formation of long-lived memory.
Signaling by the inflammatory cytokine TNF is tightly regulated. Venuprasad and colleagues show that ubiquitin modification of the kinase TAK1 by Itch and Cyld terminates TNF signaling.
The transcription factor STAT5 commonly activates gene transcription. Clark and colleagues show that tetrameric STAT5, induced by high concentrations of interleukin 7, can repress gene expression by recruitment of the histone methyltransferase Ezh2.
The priming of an antibacterial response requires the uptake and presentation of bacterial antigens by dendritic cells. Busch and colleagues describe a new platelet-dependent mechanism for shuttling bacteria to dendritic cells.
The stability of interleukin 6 transcripts is negatively regulated by the RNAse regnase-1. Akira and colleagues show that regnase-1 is targeted for degradation by phosphorylation mediated by the kinase IKK, which allows more interleukin 6 production.
The identification of an endogenous ligand for natural killer T cells has remained elusive. Brenner and colleagues identify β-d-glucopyranosylceramide as a physiologically important self ligand for these cells.
The deubiquitinase A20 is a negative regulator of transcription factor NF-κB signaling pathways. Ma and colleagues show that mice lacking A20 expression in dendritic cells have defective lymphocyte homeostasis and develop spontaneous inflammatory disease.
Type 2 cytokine–producing innate lymphoid cells are present in human and mouse lungs, where they contribute to both type 2 immune responses and tissue repair.