Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Autoreactive CD8+ T cells are prevalent in multiple sclerosis. Goverman and colleagues identify tumor necrosis factor–inducible nitric oxide synthase (TNF-iNOS)-producing dendritic cells that cross-present myelin antigen to activate naive CD8+ T cells in the central nervous system.