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Every instance of a variant in the human genome causing or correlated with a trait deserves to be databased and analyzed. As a consequence of rapidly evolving technology and strategies, more of the mutational spectrum of human disease is now accessible to research. Advised by our referees' progressively higher standards, we continue to select the most informative and useful results.
How can we get more therapies into preclinical testing and increase the proportion that succeed in preclinical testing? How can we increase the efficacy of therapies? How can we ensure that therapies are developed for rare diseases?