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This study shows that Aβ from transgenic host tissue is able to enter and deposit within wild-type grafts via microglia, thus identifying microglia as carriers of Aβ deposition into previously unaffected brain tissue.
The conventional view is that the cortex generates brain oscillations, while subcortical structures control global sleep–wake switching. This study shows that the cortex plays an important role in both global state control and sleep homeostasis.
Hippocampal ~8-Hz theta rhythmicity is enhanced in virtual reality, seen in the local field potential, pyramidal cells and interneurons. It is accompanied by the emergence of a novel ~4-Hz eta rhythm, seen in the local field potential and interneurons.
Eiselt et al. report conditions under which mice confuse thirst for hunger, similar to some human decisions that lead to over-eating. Evaluation of physiological need state requires consuming food or water and depends on the prefrontal cortex.
Rare rewards amplify dopamine neuron responses, even when conventionally defined prediction errors are identical. This suggests that individual dopamine neurons are sensitive to predicted reward distributions and can facilitate the learning of complex incentive structures.
Gava et al. explore the organization of neuronal co-activity in hippocampus from a graph theoretical perspective to report how new associative memories integrate into the network and restructure the neural patterns representing prior memories.
