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Neuronal activity stimulates a genetic program to rapidly generate synapses during development
In Caenorhabditis elegans, loss of the transcription factors FOS-1 and EGL-43 — orthologs of human FOS and MECOM, respectively — severely reduces presynaptic gene expression in dopaminergic neurons. These transcription factors form an activity-regulated positive feedback loop, which modulates the expression of synaptic genes and genetic programs to promote synapse formation.
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Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress
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Proteomic changes in Alzheimer disease associated with progressive Aβ plaque and tau tangle pathologies
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Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs.
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Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells