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Prime concerns of Li-S batteries revolve around the sulfur’s utility ranging from its performance to safety concerns. Here, the authors use biomacromolecular binder imparting conformal property to trigger high sulfur reactivity and modulate polysulfides while manifesting flame retardability.
Critically lists tend to ignore the fact that most metals are largely used in alloy form. Here the authors analyze four key metrics and show that six critical metals can be singled out for enhanced concern – Dy, Sm, V, Nb, Te, and Ga.
Forest dynamics are monitored at large scales with remote sensing, but individual tree data are necessary for ground-truthing and mechanistic insights. This study on high temporal resolution dendrometer data across Europe reveals that the 2018 heatwave affected tree physiology and growth in unexpected way.
Variable dominance of distinct microbial communities during the late Ediacaran, recorded in C and N cycles perturbations and in Raman structural heterogeneities of organic matter, modulated the recovery from the most negative δ13Ccarb excursion in Earth’s history.
There are a lack of tools to study the dynamics of (pseudo)hypohalous acids in live cells. Here the authors report a genetically encoded fluorescent biosensor, Hypocrates, for (pseudo)hypohalous acids and their derivatives which they use in cells and in a zebrafish tail fin injury model.
While evidence is constantly changing during real-world decisions, little is known about how the brain deals with such changes. Here, the authors show that the brain strategically suppresses motor output via the frontal eye fields in response to stimulus changes.
Loneliness and social isolation (LNL-ISO) are associated with schizophrenia. Here the authors demonstrate the role of shared heritability, bidirectional causal relationships and significant differences by sex, illustrating the genomic footprint of social isolation on schizophrenia.
Life- and healthspan of organisms can be modulated by dietary, genetic, or pharmacological interventions, which often affect metabolic pathways. Here the authors report that Grainyhead 1 is an evolutionarily conserved, drug-inducible transcription factor that promotes longevity in C. elegans, and thus a potential target for the development of geroprotective drugs.
TCPTP is a non-receptor type protein tyrosine phosphatase involved in various signalling pathways. Here, the authors provide structural insights into TCPTP activation, showing that TCPTP is inhibited by its C-terminal tail, which can be displaced by the cytosolic tail of integrin-α1, leading to activation.
The changes that prostate cancer (PCa) induces in its microenvironment are not fully understood. Here the authors use single-cell RNA-seq and organoids to characterise how the microenvironment responds to PCa, and also identify tumour-associated epithelial cell states and club cells.
Prioritizing drug repurposing candidates for downstream studies remains challenging. Here, the authors present a high-throughput approach to identify and validate drug repurposing candidates, integrating human gene expression, drug perturbation, and clinical data from publicly available resources.
One pathway for improving the performance of optoelectronics is the tailoring energy bands of the charge transport layer. Here, Kim et al present a charge transfer complex composed out of nanodomains of MoO3 embedded within an NiO matrix, significantly improving green and blue OLED performance.
Patients with pancreatic cancer have a poor prognosis, more research is required to identify the disease at an earlier stage. Here, the authors use lipid profiles of blood samples and show that they can distinguish patients with pancreatic cancer from healthy controls.
China’s transition path toward carbon neutrality remains uncertain. Here the authors combine Monte Carlo analysis with an energy-environment-economy model to present a probabilistic view of China’s energy transition across 3,000 cases.
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
The domestic chicken Gallus gallus domesticus is a classic model for the study of folliculogenesis. Here the authors integrate multi-omics analyses characterizing the dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis.
Exploiting technologies derived from the optical clocks community, the authors demonstrate a setup for twin-field QKD which extends the coherence times by three orders of magnitude, overcoming the main challenge towards real-world implementation.
The study of the brain’s low-dimensional topology enables the dynamic tracking of changes in neural activity. Here authors show how the reshaping of low-dimensional trajectories of brain activity sustain cognition following focal neural perturbations.
Applications of nanophotonic tweezers have been limited by the low trapping force. Here, the authors present enhanced force generation in a nanophotonic standing-wave array trap by integrating a critically-coupled resonator design and demonstrate common single-molecule experiments.
Ordinary differential equation (ODE) models are widely used to understand multiple processes. Here the authors show how the concept of mini-batch optimization can be transferred from the field of Deep Learning to ODE modelling.