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Chemical interaction between metal and oxide supports is an important molecular-level factor that influences the catalytic selectivity of a desirable reaction. Here, using Pt nanowires/TiO2 catalytic nanodiodes, the authors investigate an enhancement of both selectivity and hot electron generation on metal-oxide interfacial sites.
Four-dimensional (4D) printing of shape memory polymer (SMP) imparts time responsive properties to 3D structures. Here, the authors explore 4D printing of a SMP in the submicron length scale, extending its applications to nanophononics.
Liquid-liquid phase separation of p62/SQSTM1 has been previously described, although the significance in vivo remains unclear. Here the authors show p62 droplets contain ubiquitin, autophagy-related proteins and Keap1 to serve as platform of not only autophagosome formation but also Nrf2 activation.
Covalent organic frameworks (COFs) are promising materials for separation membranes, but their wide pores prevent selective gas separation through molecular sieving. Here, the authors demonstrate a Metal-organic framework (MOF)-in-COF membrane with a significant enhancement of separation selectivity of hydrogen over other gases.
Here, the authors profile the oral phageome of 4 healthy individuals via longread shotgun metagenomics using PromethION, a recently developed highthroughput nanopore sequencer, and uncover potential new candidate phages with enhanced scaffolding and their interaction with host bacteria.
The emergent excitation dynamics of an ultracold gas of Rydberg atoms exhibits features analogous to epidemic spreading on networks. Wintermantel et al. propose a controllable experimental system for studying network dynamics at the interface of mathematical models and real-world complex systems.
COPA regulates Golgi to ER transport, and mutations lead to autoinflammation and disease through poorly understood mechanisms. Here, the authors show that disease-causing COPA variants prevent STING transport from the Golgi to the ER, leading to cGAS-independent activation of the STING pathway.
Autophagy is known to promote cellular survival upon starvation, although how recycled components fit into cellular metabolism has not been well established. Here, the authors show in yeast that autophagy tunes cellular metabolism based on nitrogen availability via glutamate and aspartate synthesis.
A theoretical framework to optimize photonic structure designs for upconversion enhancement is lacking. Here, the authors present a comprehensive theoretical model and confirm the model’s predictions by experimental realisation of 1D-photonic upconverter devices with large statistics and parameter scans.
Efficient and stable perovskite solar cells with simple active layers are desirable for manufacturing, yet formation of a two-dimensional component in the perovskite film compromises the performance. Here, the authors report low temperature fabrication of highly efficient and stable inverted solar cells by adding a fluorinated lead salt.
Unlike RORα, which has been thought to be somewhat redundant, RORγt has been well characterized in its function and contribution to the development of Th17 cells. Here the authors show that RORα is important in Th17 differentiation and that RORα deletion or a small molecule inhibitor of RORα can reduce disease in EAE and colitis mouse models.
High resolution imaging of large biological volumes typically takes a long time from hours to days. Here the authors use a Bessel light-sheet approach combined with a content-aware compressed sensing computational pipeline to image whole mouse organs at subcellular resolution in a few minutes.
Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.
Nanopore sequencing technologies applied to transcriptome analysis suffer from high error rates, limiting them largely to reference-based analyses. Here, the authors develop a computational error correction method for transcriptome analysis that reduces the median error rate from ~7% to ~1%.
Integration of single cell data modalities increases the richness of information about the heterogeneity of cell states, but integration of imaging and transcriptomics is an open challenge. Here the authors use autoencoders to learn a probabilistic coupling and map these modalities to a shared latent space.
In most model yeast species the Origin Recognition Complex (ORC) binds defined and species-specific base sequences while in humans what determines the binding appears to be more complex. Here the authors reveal that the yeast’s ORC complex binding specificity is dependent on a 19-amino acid insertion helix in the Orc4 subunit which is lost in human.
The specific capacity of P2-type sodium-ion battery cathode is limited because full extraction of Na ions leads to structural degradation. Here authors report pillar-beam structured material to overcome this issue by using K pillar ions to uphold the transition metal layers upon extraction of Na ions.
Telomerase expression and the alternative lengthening of telomeres pathway are hallmarks of cancer. Here, the authors show that, in primary brain tumors, these features are correlated with metabolic signatures detectable by metabolic imaging, suggesting that they can be used to non-invasively monitor telomere maintenance in brain tumours.
LTP and LTD are involved in shaping hippocampal place field representations. Here, the authors show that de novo pathway-specific hippocampal LTD changes dynamics and stability of newly formed place fields, regulating acquisition and maintenance of novel spatial information in adult rats.
The axon initial segment (AIS) is critical for action potential initiation and implicated in the regulation of neuronal excitability. The authors describe bidirectional AIS plasticity in a behaviourally relevant context, revealing that the AIS acts in vivo as a homeostatic regulatory domain.