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Here the authors report an NIR-II gold probe for identification of early-stage AD. The probe enables non-invasive NIR-II imaging of elevated CTGF in brains of early AD mice and multimodally identifying AD patients’ brain sections before obvious Aβ deposition.
The authors propose a method for de-scanning the axial focus movement in the detection arm of a fluorescence microscope, enabling aberration-free, multi-color, volumetric imaging. They acquire dual-colour image stacks with an axial range of 70 μm and camera-limited acquisition speed.
Individuals with autism often exhibit social memory impairment. Here, authors show the disruption of autism-associate Shank3 gene in more than a certain proportion of hippocampal ventral CA1 neurons impairs social memory, through AAV- and extracellular vesicle-mediated in vivo gene editing.
Here, the authors provide evidence for the potential of CHIT1 concentration in the cerebrospinal fluid at diagnostic lumbar puncture as a biomarker for disability progression in multiple sclerosis (MS) as it reflects early microglial activation in active lesions of MS patients.
The authors use angle-resolved photoemission spectroscopy (ARPES) and scanning tunneling microscopy (STM) to study the charge density wave (CDW) in the kagome material ScV6Sn6. The ARPES data shows minimal changes to the electronic structure in the CDW state, while STM quasiparticle interference measurements imply a strong reconstruction of the electronic structure in the CDW state.
Ultra-low temperature resistant adhesives are desirable for their potential use in polar areas or space exploration. Here, the authors develop a low-temperature tolerant adhesive with high adhesion strength in a wide tolerable temperature range and long-lasting adhesion effect that exceeds the classic commercial hot melt adhesives.
Poor access to suitable light-sheet microscopes remains a big obstacle for many end-users in biomedical research. Here, the authors present descSPIM, a low-cost, low-expertise light-sheet microscope for routine 3D imaging of cleared samples.
Unbiasedly benchmarking SRT computational methods remains a pressing challenge. Here, authors develop scCube, a simulation framework enabling scalable, reproducible, and unbiased generation of simulated SRT data, allowing researchers to benchmark and evaluate different methods.
Carboxylic acids are excellent theoretical candidates for alkylation reactions given their low cost and high availability as products from traditional and also modern feedstock derivatization reactions. Here the authors use simple carboxylic acids to functionalize the C–H bonds of electron-rich arenes under electroreductive conditions with a titanium catalyst.
Activated B cells and T cells accumulate within joints of patients with rheumatoid arthritis. Here, the authors use single-cell transcriptome and repertoire profiling to identify clonally expanded synovial B cells and T cells and define their phenotypes and predicted cell-cell interactions.
The accumulation of AGEs is closely related to the atherosclerotic calcification in diabetic patients. Here, the authors find that VSMC NF90 knockout attenuates diabetic atherosclerotic calcification by mediating the metabolic imbalance of AGEs.
The molecular mechanisms underlying metabolic remodelling in colorectal cancer (CRC) are not completely elucidated. Here, they authors show that the oncogenic protein MYG1 promotes CRC progression not only through regulating mitochondrial activity, but also through activating a nuclear-associated pathway for glycolysis increase.
Sickle cell disease is a blood disorder that originates from a single point mutation in the HBB gene that codes for hemoglobin. Here, Moiani et al. developed an efficient TALEN-mediated HBB correction process that is compatible with gene therapy applications.
A major advantage of antiferromagnets for applications is the lack of stray fields and insensitivity to magneto-electric perturbations, however, this also makes electric control of AFMs challenging. Here, focusing on a non-collinear AFM, Mn3Ge/Sn, Wu et al demonstrate fast domain wall motion, with remarkably low current density, and extend our understanding of spin-transfer torques that drive this to noncollinear antiferromagnetic systems.
New technologies assay tissue slices for cell locations and molecular markers, aiding in the study of tissue cellular organisation. Here, authors develop an experimental design method to improve the cost-efficiency of spatial genomics experiments by iteratively selecting the most informative tissue slices.
Here the authors develop a dispersive Fourier transform (DFT) based LIDAR method utilizing phase-locked Vernier dual soliton laser combs and demonstrate improved precision in the measurements.
Devices based on microbial biofilms can be used to generate hydrovoltaic energy from water evaporation. Here, Ren et al. show that, in addition, electroautotrophic bacteria can use evaporation-induced hydrovoltaic electrons for growth in biofilms.
Here the authors report spaceflight secretome profiles by integrating plasma proteome, metabolome, and extracellular vesicles/particles proteome from the SpaceX Inspiration4 crew, which showed differences in coagulation, oxidative stress, and brain-enriched proteins.
The phenotype and function of immune cells could change during spaceflight. Here the authors use simulated microgravity, coupled to validation with spaceflight data, to assess whether there are distinct gene expression changes in resting and TLR 7/8 stimulated PBMCs and found conserved changes in IFN signalling, the cytoskeleton, IL-6 and sirtuin signalling.
Twisted 2D magnets provide a rich playground for potential spintronic device architectures. Here, the authors use tunneling magnetoresistance measurements to investigate the collective spin states of twisted double bilayer CrI3 in various configurations, providing evidence of non-volatile spin textures.