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Docking virtual libraries against protein structures has identified potent ligands for multiple targets. A comprehensive analysis reveals that the increased size of virtual libraries improves receptor fit but diverges from bio-like molecules.
Development of a chemoproteomic platform to globally interrogate Fe–S cluster incorporation in a native proteome enables the elucidation of Fe–S biogenesis components and the identification of unannotated Fe–S proteins.
Development of a quantitative approach to determine how far a signal from a cell travels as a diffusible molecule reveals a millimeter-scale quorum sensing mechanism that determines collective growth of differentiating embryonic stem cells.
DNA damage results in the acetylation of the cell-cycle checkpoint kinase WEE1 at Lys177 enabling activation. The deacetylase SIRT1 directly associates with and modifies WEE1 to inactivate it enabling resistance to WEE1 inhibition in cancer cells.
Guo et al. report a small molecule agonist of mitochondrial fusion that activates MFN1, an outer mitochondrial membrane protein, and protects cells from mitochondrial damage and ischemia/reperfusion injury in a mouse model.
Tryptophan C-mannosyltransferase (CMT) enzymes append a mannose to the first tryptophan of select sequences, which is important for the trafficking, folding and function of secretory and transmembrane proteins involved in cellular communication processes. A study reveals the structure, mode of peptide recognition and catalytic mechanism for the eukaryotic C-mannosyltransferase DPY19.
Heparan sulfate proteoglycans are extended disaccharide co-polymers containing decorations of sulfation and epimerization linked to cell surface and extracellular matrix proteins that contribute to cell signaling and tissue homeostasis. This structural and mutagenic study on the EXT1–2 complex explains molecular details of the backbone co-polymer synthesis.
A machine-learning method called MetalNet was developed to systematically predict metal-binding sites in proteomes using sequence co-evolution, which enabled the identification of new metalloproteins.
