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    Chemical biology and systems biology are beginning to intersect with increasing frequency, opening up opportunities for integrating new tools and concepts into both fields. In this issue, we highlight a number of exciting areas at the emerging interface of 'chemical systems biology'.

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    New mechanistic insights are extending our understanding of cooperativity in biochemical processes. In this issue, we feature a collection of articles highlighting current research and future challenges in exploring cooperative systems in chemistry and biology.

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    In this issue, we highlight important recent advances in understanding both the chemistry and biology of metals in biological systems. We also feature new tools and approaches that can be used to gain a better understanding of the roles that metal ions play in cells and in whole organisms. We hope this collection of articles highlights the excitement of the 'chemical biology' of metals.

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    Cells and organisms have developed specialized systems to observe and respond to variables within their local environments. In this issue, we feature a collection of articles that focus on how biological systems measure space and time.

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    Investigations into natural products have recently regained prominence with the increasing understanding of their biological significance and increasing recognition of the origin and function of their structural diversity. This issue highlights some of the major questions and advances in natural products research, from recent synthetic approaches to access complicated natural products to a new educational program which utilizes natural products as a basis for discovery-based research.

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    RNA has occupied a pivotal position in the 'central dogma' of molecular biology, which states that information flows from DNA through RNA to proteins. In this issue, we feature a collection of articles that discuss the diverse functional roles of RNA in biological systems and highlight recent discoveries in RNA chemical biology, including advances in transcription, RNA structural biology, RNA interference and RNA engineering.

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    The development of new therapeutic agents has required the close collaboration of chemists and biologists in identifying drug targets or lead compounds and developing them toward the clinic. This month we include a series of articles that focus on how chemical biologists in academic and industrial settings enhance our understanding of biological systems and advance the next generation of therapeutic agents.

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    The June 2006 issue represents one year of Nature Chemical Biology. To mark our anniversary, we have compiled some highlights from our first 12 issues. These free items reflect the editorial scope and the diversity of content featured in Nature Chemical Biology. We hope that you will enjoy them and look forward, with us, to our second year of publication of research at the interface of chemistry and biology.