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  • Focus |

    In this issue, we present a collection of articles that tackle the challenges in the discovery and validation of new targets for clinical purposes, the application of chemical probes to understand the relationship between targets and biology and the expanding assortment of chemical tools and techniques that can be used to perturb targets that have been considered chemically intractable.

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    Metabolism is moving beyond flat biochemical charts into three dimensions, where dynamics in time and space lead to distinct biological outcomes and manipulation of metabolic pathways have the potential to address medical and societal needs. In this focus issue, we feature a collection of commentary and review articles that outline some of the ideas, advances and goals that are laying the foundations for the next era of metabolism research.

  • Focus |

    Small molecules play important roles as metabolites in the physiology, ecology and evolution of microorganisms. This issue includes a collection of articles aimed at understanding the chemical interactions of microbes with their environment, with an aim towards new anti-microbials and new biological insights.

  • Focus |

    Chemical biologists continue to discover how cells translate chemical or physical inputs into biological outputs. This issue includes a collection of articles that delineates the complexity of these switches, highlighting current ideas and future challenges in this research arena.

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    Big science' initiatives and investigator-driven 'small science' research in chemical biology will both contribute to a more integrated view of biological systems.

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    This special issue presents a collection of articles exploring the foundations of chemical biology, reviewing some of the major technical and conceptual advances of the last decade, and imagining the future of this vibrant field.

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    Chemical biologists are asking and answering molecular level questions that expand our awareness and understanding of structural and functional variation. In this issue, we feature profiles, opinions and guides that highlight the complexity of the natural world.

  • Focus |

    This themed issue features a collection of articles that describe our current understanding of the functions of lipids and the chemical methods used to study them at the individual level and within the larger biological systems where they function.

  • Focus |

    Chemical biologists are making significant progress in discovering and characterizing high-quality chemical probes. In this issue, we feature Commentary and Review Articles that capture opinions and advances at the frontiers of chemical probe research.

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    This special issue contains a collection of articles that discuss our current understanding of protein dynamics and the methods used to study the dynamics of individual proteins and their interactions with the larger biological systems where they function.

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    Insights gained from advanced techniques and large datasets are charting new courses in enzymological research. In this issue, we feature a collection of articles highlighting the current ideas and future challenges that are redirecting research in the field.

  • Focus |

    Enhanced interactions between plant biology and chemical biology offer great potential for shared concepts, tools and insights that will advance each discipline. This special issue highlights emerging frontiers in plant chemical biology, with an emphasis on the networks of plant hormones that regulate plant growth and mediate plant interactions with their external environments.