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Griess et al. determine the lipid signatures of pancreatic islets in type 2 diabetes models. They define a lipid environment linking the endoplasmic reticulum–Golgi transport protein Tmed2 to the proinsulin processing enzyme Pcsk1 to ensure insulin production.
Lolo et al. show caveolin-1 functions in non-caveolae structures termed dolines. Whereas caveolae respond to high forces over a mechanical threshold, dolines transduce low and medium mechanical forces gradually in a complementary buffering system.
Maan et al., Meier et al. and Song et al. report that microtubule plus-end binding proteins can undergo liquid–liquid phase separation to regulate microtubule dynamics.
Maan et al., Meier et al. and Song et al. report that microtubule plus-tip end binding proteins can undergo liquid–liquid phase separation and regulate microtubule dynamics.
Maan et al., Meier et al. and Song et al. report that microtubule plus-tip end binding proteins can undergo liquid–liquid phase separation and regulate microtubule dynamics.
Allen et al. identify a pathogenic role for microbial small RNAs enriched on low-density lipoprotein to activate TLR8 signalling, thereby promoting polarization of inflammatory macrophages and facilitating the development of atherosclerosis.
Bae et al. engineer mesenchymal stem cells to express and deliver IL-2 to tumour-infiltrating lymphocytes, leading to activation and expansion of CD8+ T cells and improved tumour control, overcoming adaptive resistance to immune checkpoint blockade.
Efstathiou et al. describe an Argonaute-dependent endoplasmic reticulum (ER)-associated RNA silencing pathway that acts together with ER-associated protein degradation to preserve ER homeostasis and function.
Kwak et al. report that adherens junctions organize membrane microdomains, leading to lipid-dependent γ-secretase recruitment and size-dependent protein segregation, excluding full-length Notch receptor.
Zhang et al. have data suggesting that, in the chicken embryo, monocytes foster a pro-angiogenic microenvironment in advance of angiogenesis by depositing migrasomes enriched in angiogenic factors.
Lim et al. developed a fluorescence resonance energy transfer-based assay to identify anti-CRISPR molecules and discovered an SpCas9 inhibitor that is twofold more efficient in inhibiting Cas9 at diverse genomic loci than existing inhibitors and easy to synthesize.
Cockburn et al. report that epidermal differentiation is a multi-day process through which cells undergo a continuum of transcriptional alterations initiated independently of cell cycle exit.
Truong et al. report a system to monitor RNA expression by modifying an intron within a gene of interest. This additional engineered transcript then hijacks nuclear export machinery for subsequent translation of a reporter gene.
Planelles-Herrero et al. identify a function for the Elongator complex independent of its enzymatic activity in controlling microtubule stability and generating central spindle asymmetry during asymmetric division in Drosophila.
Blanco et al. show that PTEN loss results in accumulation of type-17 innate-like T cells via altered metabolic reprogramming and mTOR, Foxo1 and IL-23–Stat3 signalling.
Kuiper et al. and Prophet et al. implicate DNAJB6/HSP70 chaperone activities in the biogenesis of the nuclear pore complex permeability barrier and find that disease-linked nuclear envelope blebs are enriched in nucleoporin and chaperone condensates.
Kuiper et al. and Prophet et al. implicate DNAJB6/HSP70 chaperone activities in the biogenesis of the nuclear pore complex permeability barrier and find that disease-linked nuclear envelope blebs are enriched in nucleoporin and chaperone condensates.
Wang and colleagues identify a protein phosphatase role for the metabolic enzyme fructose-1,6-bisphosphatase 1 that, upon phosphorylation by PERK, dephosphorylates histone H3 and modulates PPARα-mediated gene expression to inhibit liver cancer progression.
Zhang et al. report that the long noncoding RNA KCNQ1OT1 binds to double-stranded genomic DNA and to the heterochromatin protein HP1α to induce and maintain epigenetic silencing at repetitive DNA elements and guard against genomic instability and senescence.
Tanaka et al. generate human induced pluripotent stem cell-derived salivary gland organoids that serve as a model for salivary gland development and SARS-CoV-2 infection.