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Xie et al. show that efficient miRNA biogenesis in Arabidopsis requires the assembly of pre-miRNA processing bodies mediated by SERRATE phase separation.
Chitiashvili et al. report that X-chromosome dosage compensation is achieved via X-chromosome dampening in human female primordial germ cells (hPGCs) and reveal that the lncRNA XACT is a hPGC marker.
Lamm et al. report that replication stress activates mTOR through ATR to induce nuclear actin polymerization, facilitating the recovery from replication stress.
Espanola et al. show in zebrafish that Supt16h, a component of the FACT complex, regulates HSC development through an increase of p53, which promotes expression of phc1, a transcriptional repressor of Notch.
Haltalli et al. show that Plasmodium berghei infection induces interferon release, and affects haematopoietic stem cell proliferation and function, as well as osteoblasts and vascular integrity, in the bone marrow niche.
Luo et al. report that heat stress activates YAP to launch the heat shock transcriptome through inducing dephosphorylation and degradation of LATS independent of the upstream kinases MST and MAP4Ks.
Nguyen et al. show in mouse testes that germ cells are eliminated via apoptosis if they fail to differentiate properly due to errors in epigenetic reprogramming, a process that improves gamete quality.
Intracellularly regulated PI3K activation. Thapa et al. find that phosphatidylinositol-3,4,5-trisphosphate generation and Akt activation occur at intracellular membranes, rather than the plasma membrane, and that this is mediated by MAP4, which controls PI3Kα localization to microtubules.
Zhang et al. report that the lncRNA H19 stabilizes dystrophin by competing with the ubiquitin E3 ligase TRIM63 for association with dystrophin, thereby alleviating muscular dystrophies.
García-Prat, Perdiguero, Alonso-Martín et al. show that skeletal muscle contains a subpopulation of quiescent stem cells, maintained by FoxO signalling, that is preserved into late life but declines in advanced geriatric age.
Saliakoura et al. find that PLCγ1 is suppressed in hypoxic KRAS-mutant lung cancer cells, which impairs Ca2+ entry into the mitochondria and promotes glycolysis to enhance tumour progression.
Ros et al. show that the ER-resident chaperone calnexin (Cnx) and its partner ERp57 are trafficked to cell surface invadosomes and induce ECM degradation, promoting tumour invasiveness.
Aharonov et al. use in vivo genetic approaches to show that ErBB2-mediated YAP activation initiates epithelial–mesenchymal transition-like processes and dedifferentiation of cardiomyocytes to drive heart regeneration.
Cassandras et al. show that Gli1-expressing mesenchymal stromal cells promote metaplastic differentiation of airway progenitors into basal cells by antagonizing BMP signalling in lung fibrosis.
Gao et al. identify a piRNA, CHAPIR, that targets the m6A methylation of PARP10 and promotes the GSK3β-induced accumulation of nuclear NFATC4, thereby modulating cardiac hypertrophy and heart function upon pressure overload.
LRRC31 links DNA repair and radiation efficacy Chen et al. perform a genome-wide CRIPSR screen and identify LRRC31, which interacts with Ku70/80 to suppress DNA repair and enhances the efficacy of radiation therapy in breast cancer brain metastasis.
Nakamura et al. find that the master transcriptional regulator of lysosomal biogenesis and autophagy TFEB is activated following LC3 lipidation during lysosomal damage and show the importance of this mechanism during kidney injury.
Lynch et al. demonstrate that inhibiting CDK8 and CDK19 kinases increases Mediator-driven recruitment of RNA Pol II to promoters and enhancers, therefore stabilizing the naive transcriptional program.
Phase separation concentrates mitochondrial RNA granules. Here Rey et al., show that mitochondrial RNA granules (MRGs) behaviour is consistent with liquid–liquid phase separation (LLPS) and their fusion coincides with mitochondrial remodelling.