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Giancotti and colleagues report that the Rnd1 Rho GTPase suppresses the epithelial–mesenchymal transition and mammary tumorigenesis by inhibiting Ras-MAPK signalling through a Plexin B1–Rap1–p120 Ras-GAP signalling axis.
Imajo and colleagues report that the Hippo signalling pathway components YAP and TAZ act via TEAD to promote intestinal stem/progenitor cell proliferation and via Klf4 to trigger their differentiation.
Sahai and colleagues delineate a pathway through which components of the STRIPAK complex promote amoeboid cancer cell migration by regulating the linkage of the actomyosin network to the plasma membrane.
Pagano and colleagues find that Plk1 and the E3 ubiquitin ligase SCFβTrCP mediate degradation of the centrosome cohesion protein Cep68 and show this mediates removal of Cep215 from the PCM and subsequent centriole separation in late mitosis.
Rosen and colleagues perform epigenomic and transcriptomic analyses of insulin-resistant cells, and report that the vitamin D receptor and glucocorticoid receptor mediate transcriptional responses that promote insulin resistance.
Moisan, Cowan and colleagues perform a small-molecule screen to identify compounds that promote white-to-brown adipocyte conversion in vitro. They report that two inhibitors of the JAK–STAT signalling pathway stimulate browning of human adipocytes.
Wu and colleagues report that under hypoxic conditions the LATS2 kinase is targeted for degradation by the SIAH2 ubiquitin ligase, leading to inhibition of the Hippo kinase cascade and activation of YAP, which promotes tumour growth.
mTOR signalling both inhibits autophagy and promotes cell proliferation. Cecconi and colleagues report that AMBRA1 links these two processes by facilitating dephosphorylation and degradation of the proto-oncogene c-Myc.
Through biochemical and single-molecule analyses, Vallee, Gross and colleagues characterize how subdomains of the dynactin subunit p150 regulate dynein movement along microtubules.
Kronenberg and colleagues report that mesenchymal progenitor cells in endochondral bones express chondrocyte markers. By lineage tracing, they see that this population contributes to chondrocytes, osteoblasts and stromal cells in postnatal bones.
Schumacher and colleagues find that the FOXO transcription factor DAF-16 is activated in response to DNA damage in C. elegans and promotes developmental growth in a manner involving EGL-27.
Zhang and colleagues report that starvation reduces O-GlcNAcylation of the SNARE protein SNAP-29. This promotes formation of a competent SNARE complex that increases autophagosome–lysosome fusion, increasing autophagosome maturation and flux.
Using time-lapse imaging Hadjantonakis and colleagues have characterized the intercalation of definitive endoderm progenitors into the overlying visceral endoderm during mouse gastrulation and demonstrated a role for the transcription factor SOX17 in this process.
Saurin, Kops and colleagues suggest that rapid spindle assembly checkpoint (SAC) responsiveness is mediated by a mechanism in which active SAC recruits PP2A, leading to PP1 recruitment, which in turn displaces PP2A and shuts off the SAC.
Dynlacht and colleagues report that Foxk transcription factors inhibit the induction of autophagy by recruiting Sin3A–HDAC complexes to autophagy-promoting genes to limit their expression.
Ferroptosis is a form of non-apoptotic cell death with unclear physiological relevance. Conrad and colleagues now report that unrestrained ferroptosis can lead to renal failure. They also identify a small molecule that limits ferroptosis in vivo.
By live imaging and laser microsurgery, Maiato and colleagues characterize how the chromokinesin, dynein and CENP-E motor proteins cooperate to congress chromosomes peripheral to the spindle poles of the metaphase plate in mitosis.
Beachy and colleagues demonstrate that reduced Hedgehog (Hh) signalling at the tips of nascent buds allows stromal production of hepatocyte growth factor (Hgf), whereas in surrounding cells Hh inhibits Hgf through induction of miR-26a and miR-26b.
Clarke and colleagues show that TLR2–MYD88 cancer-cell-intrinsic signalling is involved in mammary and colon epithelial regeneration and tumour formation.
Through gene knockout experiments, Sicinski and colleagues reveal a role for cyclin C as a haploinsufficient tumour suppressor in T-cell acute lymphoblastic leukaemia, acting through phosphorylation of intracellular Notch1, mediating its degradation.