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Hata et al. report that minus-end-directed kinesin KIFC3 promotes centrosome cohesion at the onset of mitosis, counteracting centrosome separation driven by the plus-end-directed kinesin EG5.
Sharir et al. overhaul the classical model and show that proliferating inner-enamel progenitors generate all epithelial lineages and their Notch1-expressing progeny convert into ameloblasts after injury.
Zhang et al. report the role of CaMKII-δ9, a previously less-studied isoform, in driving cardiomyopathy. Mechanistically, CaMKII-δ9 phosphorylates UBE2T, resulting in its degradation and impairing DNA repair.
Wallroth et al. uncover a mechanism by which protein
kinase N activates mTORC1 nutrient signalling at the lysosome by
inhibiting PI3KC2-β-mediated PtdIns(3,4)P2
synthesis downstream of mTORC2.
Kim et al. demonstrate neutrophil- and macrophage-enriched subtypes in triple-negative breast cancer and how these immune profiles affect therapeutic responses to immune checkpoint blockade.
Yu and colleagues report that migrasome formation depends on tetraspanin and cholesterol. Macrodomains formed by clustering of tetraspanin- and cholesterol-enriched membrane domains swell to generate migrasomes.
Yu and colleagues report the formation of migrasomes during zebrafish gastrulation. Migrasomes provide signalling molecules to guide the migration of dorsal forerunner cells, thus controlling organ morphogenesis.
Kofuji et al. demonstrate that upregulation of IMPDH2 promotes nucleostemin stabilization and nucleoli malformation, and its inactivation induces growth arrest in glioblastoma.
Boretto et al. demonstrate that organoids derived from patients with various types of endometrial pathologies can model disease traits and diversity, and can be used as a drug-screening tool.
Yeast cells segregate the old spindle pole body into the bud. Manzano-López et al. report that inverted segregation accelerates ageing due to aberrant partition of protein aggregates and damaged mitochondria.
Chen et al. provide an m5C landscape in bladder cancer and show m5C enrichment at oncogene mRNAs that promotes tumour progression. They identify YBX1 as the m5C ‘reader’ that recruits ELAVL1 to stabilize mRNAs.
Using intravital imaging, Ebrahim et al. show that actin and non-muscle myosin II assemble into polyhedral lattices around the vesicle membrane to mediate exocytic secretion in live tissues.
AMPK and Parkin keep the necrosome in check. Lee et al. show that AMPK activates Parkin and prevents RIPK1−RIPK3 complex formation by promoting RIPK3 ubiquitination, thereby negatively regulating necroptosis, inflammation and tumour initiation.
Andersen, Hannezo, Ulyanchenko et al. map cell behaviour and spatiotemporal dynamics of the sebaceous gland during homeostasis and oncogene-induced gland expansion, and show that all basal cells contribute to long-term gland maintenance.
Wu et al. demonstrate that HER2 recruits AKT1 to disrupt the STING signalosome, thereby suppressing damage-induced cellular senescence and STING-mediated antiviral and antitumour responses in vivo.
Sun et al. demonstrate that the development of bona fide liver cancer can be modelled at structural and molecular levels by introducing c-Myc into directly reprogrammed human hepatocytes with inactivated p53 and RB.
Senoo et al. show that, in response to chemoattractant stimulation, phosphorylated Rho–GDP in complex with Ras–GTP and mTORC2 promotes AKT phosphorylation to mediate cell migration.
Simunovic et al. use human embryonic stem cells to generate a three-dimensional model of a human pre-gastrulation epiblast and show that anterior–posterior symmetry breaking can be induced by BMP4 and WNT signalling.
Activating transcription factor 4 (ATF4) promotes MYC-driven tumour progression. Tameire et al. identify ATF4 and its target eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) as regulators of MYC-mediated amino acid biosynthesis and protein synthesis, thereby modulating tumour progression and survival in mice.
Janiszewska et al. show that minor subpopulations expressing IL11 and FIGF in breast cancer cells promote metastasis through altering local and systemic tumour microenvironments including neutrophils.