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Centrioles are formed from a nine-fold symmetric cartwheel structure. Using mutants of the cartwheel protein SAS-6, which alters cartwheel symmetry, Hirono, Gönczy, Steinmetz and colleagues show that the microtubule wall also determines centriole shape.
Graf and colleagues find that B cells exposed to a pulse of C/EBPα and the Yamanaka factors convert into elite-type cells that rapidly and efficiently reprogram into iPSCs, in a process that involves upregulation of Lsd1, Brd4 and Klf4.
Using mathematical simulations and a FRET tension sensor inserted into the microtubule-binding complex Ndc80, Suzuki and colleagues obtain insights into how force is generated at the budding yeast kinetochore.
Vincent and colleagues show in Drosophila wing imaginal discs that the signalling molecule Wingless is synthesized and secreted at the apical surface, and is re-internalized to be transcytosed basally, where its signalling occurs.
Following autophagy induction, lysosomes move to the perinuclear region. Xu and colleagues delineate a pathway involving PtdIns(3,5)P2-mediated activation of the TRPML1 channel and the Ca2+ sensor ALG-2 in this process.
Using live imaging of zebrafish angiogenesis, Gerhardt and colleagues observe blood-flow-regulated inverse membrane blebbing during lumen expansion, and show that actomyosin contractility is needed for both bleb retraction and lumen formation.
Receptor-interacting protein kinase 3 (RIPK3) is a key regulator of necroptosis. Seo et al. show that the E3 ligase CHIP mediates ubiquitylation and lysosomal degradation of RIPK3, thus regulating both necrosome formation and necroptosis.
Kornfeld and colleagues identify miRNAs that are dysregulated in brown adipose tissue in mouse models of obesity and ageing, and show that miR-328 targets Bace1 to promote brown adipogenesis.
By culturing rat hepatocyte doublets in microwells with controlled ECM environments, Viasnoff and colleagues show that the lumen between the cells extends anisotropically towards regions of lower intercellular tension.
By proteomics analysis of conditioned media from cells with constitutive mTORC1 activity, Yu and colleagues identify IGF binding protein 5 (IGFBP5) as a protein that is induced by mTORC1 through HIF1 and that blocks IGF-1 signalling.
Eichel et al. show that β-arrestin-mediated MAPK activation by GPCRs involves dissociation of β-arrestin from its activating GPCR, and accumulation of β-arrestin in clathrin-coated structures, where it promotes MAPK signalling.
Durocher and colleagues find that in budding yeast, the movement of chromosomes induced by DNA breaks is due to the loss of attachment of kinetochores to spindle pole bodies and of telomeres to the nuclear periphery, and may promote checkpoint arrest.
DNA resection is the first step of double-strand break repair by homologous recombination. Broderick et al. find that EXD2 plays a key role in this process by acting as an essential cofactor for the MRN complex.
Boxem and colleagues perform a yeast two-hybrid screen to identify interactions between C. elegans polarity genes, followed by an RNAi screen to identify the functions of interaction pairs in the establishment and maintenance of cell polarity in various tissues.
Nerlov and colleagues show that expression of mKitL by cortical vascular endothelial cells is important for DN1 progenitor maintenance, whereas expression of mKitL by cortical thymic epithelial cells is required for maintaining DN2 progenitor cells.
Lecuit and colleagues show that, depending on its interaction partner, the G-protein-coupled receptor Smog regulates myosin II activation in different locations during Drosophila morphogenesis.
Using ultrasensitive mass spectrometry of wild-type and mutant early mouse zygotes, Hajkova and colleagues show that 5mC loss and 5hmC accumulation are uncoupled during zygotic epigenetic reprogramming.
Yang and colleagues identify a lncRNA that controls HIF1α signalling to stabilize HIF1α under normoxic conditions, and promotes breast cancer tumorigenesis.