Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Through a proteomics approach, Qi and colleagues and Long and colleagues identify the sensor of the unfolded protein response IRE1α as an endogenous substrate of the E3 ubiquitin ligase involved in ER-associated degradation, Hrd1.
Using in vivo quantitative single-molecule fluorescence microscopy of kinesin II and OSM-3 motor dynamics in C. elegans cilia, Peterman and colleagues show that kinesin II loads cargo at the base, whereas OSM-3 transports the cargo to the tip.
Austen et al. generated talin biosensors to study integrin-based force transduction. They report that extracellular rigidity sensing requires talin’s mechanical engagement and find talin isoform-dependent effects in integrin-mediated mechanosensing.
Jackson and colleagues and Hendzel and colleagues reveal that the E3 ligase RNF138 functions in the repair of double-strand breaks by promoting CtIP accumulation and displacement of DNA-PK subunit Ku.
Ding and colleagues show that somatic cell reprogramming does not depend on Atg5-dependent canonical autophagy, but requires mitochondrial clearance in an Atg5-independent manner downstream of AMPK.
Jackson and colleagues and Hendzel and colleagues reveal that the E3 ligase RNF138 functions in the repair of double-strand breaks by promoting CtIP accumulation and displacement of DNA-PK subunit Ku.
Chiolo and colleagues find that, in a SUMOylation-dependent manner, heterochromatic double-strand breaks move to the nuclear periphery where Rad51 is recruited to continue repair.
Chen and colleagues report that the third enzyme in the oxidative pentose phosphate pathway (PPP), 6PGD, controls cancer cell proliferation by regulating LKB1–AMPK signalling. Inhibitors of 6PGD decrease tumorigenesis in mouse xenografts.
Humphries and colleagues analyse proteomic data of integrin adhesion complexes to derive a consensus integrin adhesome and characterize the temporal dynamics of adhesome component recruitment during adhesion complex assembly and disassembly.
Pucadyil and colleagues develop an in vitro technique to analyse the conformational dynamics of dynamin during membrane fission events in a real-time, high-throughput manner, using fluorescence microscopy.
Using live imaging of Xenopus and starfish oocytes and embryos undergoing cytokinesis, Bement and colleagues show that anaphase onset promotes cortical waves of Rho and F-actin, which can be modelled by reaction–diffusion dynamics.
Huynh and colleagues discover nuclear rotations driven by centrosomes, microtubules and Dynein in Drosophila germ cells, and find that these movements facilitate the pairing of homologous chromosomes.
Ivaska and colleagues report that endocytosed integrins are able to signal from endosomes in an FAK-dependent manner. They further show that endosomal integrin signalling can promote anoikis resistance and lung colonization in cancer cells.
Lomakin et al. report that the competition for actin between two distinct F-actin networks determines whether epithelial cells remain stationary or migrate, with myosin II inhibiting the migratory polarized phenotype by confining actin in contractile bundles.
Using live imaging, St Johnston and colleagues show in three Drosophila epithelia that cells born outside the epithelium do not die, but reintegrate, and that lateral adhesion is required for reintegration to occur.
Using TIRF-based in vitro reconstitution assays Surrey and colleagues characterize how chTOG and TPX2 cooperate in microtubule nucleation and find that importins regulate the process.
Lecuit and colleagues use live imaging and laser ablation approaches to show that germ-band extension of the Drosophila embryo is associated with new junction growth, which is dependent on both tissue-level and local forces.
The TERT promoter is mutated in many cancers. Li et al. show that non-canonical NF-κB signalling and ETS1/2 transcription factors are jointly needed to activate the C250T mutant TERT promoter, leading to telomerase activity and glioblastoma growth.
Through proteomics, Harper and colleagues identify proteins interacting with UBXD adaptors for the multifunctional AAA-ATPase VCP and reveal a role for UBXN10 in ciliogenesis.