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Lee, Mall et al. explore why the sequence-related transcription factors Myod1 and Ascl1 lead to different reprogramming outcomes when expressed in fibroblasts, despite binding similar targets.
Santoriello, Sporrij et al. show that the progesterone receptor associates with RNA helicase DDX21 during nucleotide depletion, promotes its binding on chromatin and rescues efficient transcription in melanoma cells.
Liu et al. show that cancer cells with high levels of SLC7A11 have increased dependency on the pentose phosphate pathway and consequently accumulate disulfide, and can be therapeutically targeted by limiting glucose supply.
Wu et al. show that TAZ can undergo phase separation and the resulting condensates locally concentrate transcriptional activators to facilitate the expression of TAZ-controlled genes.
Müller et al. provide a comprehensive resource depicting cellular substrates, localization and interacting partners of RhoGEF and RhoGAP proteins regulating the canonical Rho family of GTPases.
Zhao et al. show that H2AK119ub1 is propagated during cell division through positive feedback mediated by the variant PRC1 complex containing RYBP or YAF2 and promoted by histone H1-mediated chromatin compaction.
Nishida et al. show that DNA demethylation and super-enhancer formation upregulates the transcription of inflammation genes, thereby promoting neutrophil-mediated lung metastasis in renal cell carcinoma.
Li et al. report that PIWIL1 executes a piRNA-independent function in promoting pancreatic cancer metastasis. Mechanistically, PIWIL1 acts as a co-activator for the ubiquitin E3 ligase APC/C.
Tsang et al. show that copper modulates the activity of autophagic kinases ULK1/2 to control autophagy, and is required for KRASG12D-driven tumour growth and cancer survival in response to starvation.
Davis et al. demonstrate heterogeneous and distinct transcriptome programs in breast cancer micrometastasis associated with upregulated mitochondrial oxidative phosphorylation.
Artegiani, Hendriks et al. describe a CRISPR–Cas9-based method to efficiently generate human knock-in organoids using non-homologous end joining to study rare intestinal cell types and human hepatocyte division.
Yue, Zong, Li, Li, Zhang, Wu et al. introduce an in toto live-imaging system to track cardiac ventricle chamber formation at single-cell resolution for up to 1.5 days and digitally reconstruct cell dynamics.
Ubiquitin ligase Hrd1 is essential for endoplasmic-reticulum-associated protein degradation. Vasic et al. demonstrate that Hrd1 forms a retrotranslocation channel controlled by auto-ubiquitination and substrate binding.
Montagner et al. show that lung epithelial cells induce Sfrp2 expression and fibronectin fibril formation in disseminated breast cancer cells, thereby promoting their survival and latency in the lung.
Zheng et al. discover a type of perinuclear microtubule-organizing center, which is assembled by multiple factors and regulates retrograde endosomal trafficking and plasma membrane growth.
Li et al. demonstrate the efficacy of correcting the mutated TERT promoter using a programmable base editing, highlighting its ability to induce senescence, arrest and regression in brain tumour models.
Kim et al. develop an optogenetic visualization approach that can rapidly and reversibly trap messenger RNA molecules in protein clusters, thereby restricting their access to ribosomes and dampening translation efficiency.
Lau et al. quantify endogenous concentrations of the chemokine Cxcl12 and its binding affinity for its cognate receptor Cxcr4 in zebrafish embryos, uncovering a negative-feedback loop governing directional cell migration in vivo.
Lee et al. show that, after nitrogen starvation and genetic interference with the architecture of nuclear pore complexes, nucleoporins are degraded by autophagy, constituting a quality-control step at the nuclear envelope.
Lee et al. show that energy stress inhibits ferroptosis through AMPK activation and demonstrate a role for AMPK in ferroptosis-associated renal ischaemia–reperfusion injury in vivo.