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Wang et al. demonstrate that CD9 marks tumour-initiating cells in pancreatic ductal adenocarcinoma (PDAC), and enhances glutamine uptake to promote tumour development in vivo that recapitulates the cellular heterogeneity of primary PDAC.
Aloia, McKie, Vernaz et al. show that during liver damage ductal cells acquire cellular plasticity by undergoing epigenetic remodelling, with TET1-mediated regulation of ErbB–MAPK and YAP–Hippo signalling.
Schmidt et al. show that the translation initiation factor eIF2B5 regulates stress responses and MYC translation to prevent apoptosis, thereby presenting a targetable vulnerability in colorectal cancer.
Jaumouillé et al. show that a talin/vinculin-based molecular clutch mechanically couples the forces generated by Arp2/3- and Dia1-mediated actin polymerization to promote integrin-mediated phagosome formation.
Simonetti et al. uncover an endosomal SNX–BAR sorting complex, ESCPE-1, that coordinates sequence-dependent cargo recognition with the formation of tubulo-vesicular transport carriers for endosomal export.
Karoutas et al. report lamin A/C as a non-histone target for the acetyltransferase MOF. They find that lamin A/C acetylation prevents nuclear envelope rupture and maintains nuclear integrity.
Zhao et al. identify an unexpected role of the nuclear export factor Nxf2 as a partner of Panoramix in mediating piRNA-guided silencing. Nxf2 counteracts Nxf1-centred nuclear RNA transport to prevent the export of transposon transcripts.
Levin-Konigsberg et al. show that resorption of the phagolysosome after degradation of its contents requires transfer of PI4P and tethering to the ER, both mediated by oxysterol-binding protein-related protein 1L (ORP1L).
Pessina et al. report that DNA damage induces the assembly of a functional promoter at double-strand breaks and the transcribed RNAs promote phase separation of damage-response factors such as 53BP1.
Di Giammartino, Kloetgen, Polyzos, Liu et al. probe chromatin organization, enhancer status and transcriptional changes and show that KLF4 acts as a transcriptional regulator and chromatin organizer during induced pluripotent stem cell reprogramming and in pluripotent stem cells.
Wolf et al. show that N-Ank proteins combine their curvature-sensing ankyrin repeat array and N-terminal amphipathic helix to shape membranes, and ankycorbin shapes membrane protrusions in developing neurons.
Lim et al. show that OSBP and VAPA and VAPB deliver cholesterol across ER–lysosome contacts to activate mTORC1. OSBP-mediated cholesterol trafficking activates mTORC1 in a disease model caused by loss of Niemann–Pick C1.
Li et al. find that IFFO1 bridges the core NHEJ factor XRCC4 and lamin A/C, thus reducing the mobility of broken DNA ends to prevent chromosomal translocation in cancer cells.
Trivedi et al. find that phase separation of the chromosome passenger complex is essential for its localization and function at the inner centromere during mitosis.
Hata et al. report that minus-end-directed kinesin KIFC3 promotes centrosome cohesion at the onset of mitosis, counteracting centrosome separation driven by the plus-end-directed kinesin EG5.
Sharir et al. overhaul the classical model and show that proliferating inner-enamel progenitors generate all epithelial lineages and their Notch1-expressing progeny convert into ameloblasts after injury.
Zhang et al. report the role of CaMKII-δ9, a previously less-studied isoform, in driving cardiomyopathy. Mechanistically, CaMKII-δ9 phosphorylates UBE2T, resulting in its degradation and impairing DNA repair.
Kim et al. demonstrate neutrophil- and macrophage-enriched subtypes in triple-negative breast cancer and how these immune profiles affect therapeutic responses to immune checkpoint blockade.
Yu and colleagues report that migrasome formation depends on tetraspanin and cholesterol. Macrodomains formed by clustering of tetraspanin- and cholesterol-enriched membrane domains swell to generate migrasomes.
Yu and colleagues report the formation of migrasomes during zebrafish gastrulation. Migrasomes provide signalling molecules to guide the migration of dorsal forerunner cells, thus controlling organ morphogenesis.