Reviews & Analysis

Edited, transgene-free plants are produced without tissue culture by RNA migration from rootstocks to grafts.

Elongating protein fibers record the transcriptional activity of single cells for later readout by imaging.

By screening natural prokaryotic gas vesicle gene clusters, we found and engineered new acoustic reporter genes (ARGs) that give bacteria and mammalian cells brighter ultrasound contrast for real-time noninvasive imaging. Expressing these ARGs in engineered cells enabled us to image tumor-homing bacteria and perform genetically guided tumor biopsies in vivo.