Reviews & Analysis

A plant immune receptor is engineered to recognize viruses rather than bacteria.

An engineered recombinase removes the HIV-1 provirus from patient-derived cells and reduces infection in humanized mice.

The safety of engineered T cells is improved through gated expression of two chimeric antigen receptors.

Two new variants of the Cas9 nuclease have minimal activity at off-target DNA sites.

Mechanically stable bone, cartilage and muscle tissues are printed in custom shapes.

Short-read sequencing provides haplotype information when long DNA fragments are barcoded in microfluidic droplets.

Gene drives in mosquitoes to reduce the spread of malaria move closer, though technical and regulatory hurdles remain.

Regulatory genomic elements can now be studied in their native context using two CRISPR-based high-throughput approaches.

A systems model of glycemic response identifies individually tailored diets that keep blood sugar in check.

A method for generating serotonin raphe neurons in vitro will aid the study of genetic variants and drugs that modulate serotonin activity.

Understanding the full breadth of immune responses that protect against HIV-1 may speed vaccine development.

Two recent studies report the development of miniaturized, fully-implantable devices that enable wireless optogenetic neuromodulation in peripheral nerves and spinal cord.

The unprecedented number of fatalities in the PROPATRIA clinical trial using probiotics to treat patients with acute pancreatitis cast a shadow over the field. Bongaerts et al. provide rationales for the trial's high mortality rate and outline situations in which probiotic therapy may still be appropriate for this disease.