Reviews & Analysis

New tools for site-specific genome targeting in human cells are generated from TALE proteins.

Sequencing technologies are poised to transform conventional strategies for crop improvement.

The use of a natural IgG transport system to deliver a mucosal vaccine is a step toward needle-free immunization.

Expressing zinc-finger nucleases in zygotes enables targeted transgene integration in the mouse and rat genomes.

Experimental haplotyping of whole genomes is now feasible, enabling new studies aimed at linking sequence variation to human phenotypes and disease susceptibility.

Screening for safe harbor sites in the genome may improve the safety of gene therapy.