Reviews & Analysis

An engineered centromere-specific histone could enable homozygous diploid lines to be generated at high frequency, simplifying crop breeding.

Therapeutic inhibition of a microRNA reduces metastasis formation in a mouse model of breast cancer.

Mouse fibroblasts are reprogrammed to functional neurons by expression of a few transcription factors.

Transfer of a pattern-recognition immune receptor to a crop confers resistance to several bacterial pathogens.

Hierarchical models provide reliable statistical estimates for data sets from high-throughput experiments where measurements vastly outnumber experimental samples.

A severe inherited neuromuscular disease is corrected in mice by intravenous gene delivery.

Acute myeloid leukemia stem cells can be made susceptible to chemotherapy by inducing them to divide.

What can we learn from the first genome sequences obtained from cancerous cells?

High-throughput RNAi screens in human cells suggest new approaches to curb influenza virus infection.

Flux balance analysis is a mathematical approach for analyzing the flow of metabolites through a metabolic network. This primer covers the theoretical basis of the approach, several practical examples and a software toolbox for performing the calculations.

Machine learning reveals combinatorial patterns of transcription factor binding that drive gene expression.

New insights into the maize genome must be incorporated into breeding programs to realize the potential of crop genomics.

High-throughput measurements across several regulatory levels provide a comprehensive view of ES-cell differentiation.

A new metric called the normalized spectral index (SI_N) provides a simple way to quantify and compare label-free proteomics data.

Structural insights into the regulation of phosphodiesterase 4 lead to the discovery of allosteric modulators with reduced side effects.

Advances in technology deliver cheaper human genome sequencing.