Reviews & Analysis

Development of next-generation crops will be enabled by combining state-of-the-art technologies with speed breeding.

Transgenic cassava expressing Cas9 is not protected from geminivirus infection.

Bailey and Maus discuss cutting-edge developments in engineering immune cells towards expanding the reach and efficacy of adoptive cell therapies in cancer and beyond.

The Kipoi repository provides a home for trained machine-learning models that facilitates their sharing and reuse.

A simple chemical modification can substantially reduce the toxicity of antisense oligonucleotides.

In vivo studies indicate that cytosine but not adenine base editors induce elevated levels of genome-wide off-target substitutions.

Human brain organoids are endowed with regional topography using engineered signaling centers.

Large brain tissue sections are imaged with nanoscale resolution using expansion and lattice light sheet microscopy.

Heikenfeld et al. survey the range of biochemical analytes that can be sensed in dermal interstitial fluid, saliva and sweat, and outline criteria for tailoring sensor design to address the right analyte in the right body site for the right disease or wellness application.

Assessing progress towards designing reliable wearable biosensors reveals the challenges remaining before the promise of clinical translation can be realized.

Pere Santamaria and Pau Serra review the state of the art in antigen-specific therapies for autoimmune disease, discussing mechanism of action and clinical efficacy of each strategy.

Chien et al. reflect on lessons learned following the recent announcement that 31 papers from the Anversa laboratory on cardiac cell therapy are being retracted.

Cassava engineered to retain more iron and zinc faces challenges before moving into fields and onto forks.

The generation of immature human oocytes in vitro highlights the challenges of folliculogenesis.