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The function of the KCNH family of potassium channels is critical for the repolarization of the cardiac action potential and the regulation of neuronal excitability; here, the X-ray crystal structure of the cyclic-nuclotide-binding homology domain of the zebrafish ELK channel is reported.
The X-ray crystal structure of LeuT, the bacterial homologue of the neurotransmitter sodium symporter family, is reported in the outward-open and inward-open states.
The crystal structure of histone deacetylase HDAC3 bound to the co-repressor SMRT is reported, and suggests that inositol tetraphosphate could act as a regulator of HDAC3; this has therapeutic implications, because HDACs are emerging targets of anti-cancer drugs.
Temporal cloaking hides an event in time from being detected; here this is achieved by speeding up one end of a probe beam and slowing down the other to create a ‘time hole’ and to close it afterwards so that the signal amplitude of an event is much reduced.
Simulations reproduce previously unexplained features of Titan’s methane cycle, attributing them to atmospheric instabilities and cold-trapping of methane in the polar regions.
FBXO11 is identified as the F-box protein that normally targets BCL6 for degradation, and FBXO11 deletions or mutations that prevent this function and thus stabilize BCL6 are found in B-cell lymphomas.
Comparison of real lizards with a robotic version and a dinosaur model shows that lizards use their tails to control body pitch in aerial motion by means of transfer of angular momentum from the body to the tail.
Genome-wide mapping of oestrogen receptor-α binding sites in primary breast cancer tissues shows that oestrogen receptor binding is dynamically regulated and that the expression of genes near differentially bound regulatory regions is associated with clinical outcome.
Molecular chirality can be used to control interfacial tension in multi-component mixtures of chiral molecules, and tuning the chirality makes it possible to produce and manipulate self-assembling complex chiral structures.