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Chimeric antigen receptor (CAR) T cells engineered to overexpress the canonical AP-1 transcription factor c-Jun are resistant to T cell exhaustion, and provide enhanced therapeutic benefit in mouse tumour models.
Observations of an accretion disk around a hot white dwarf star reveal that the chemical abundances in its disk are similar to those thought to exist deep in icy giant planets, so the white dwarf must be accreting a giant planet.
Satellite-derived analysis of daily vertical migrations of ocean animals shows that the relative abundance and total biomass of these animals differ between different regions globally, depending on the availability of food and necessity to avoid predators.
Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to chloroquine and piperaquine in drug-resistant parasites.
Cryo-electron microscopy structures of the active and inhibited human CALHM2 channel suggest a two-stage gating mechanism in which the S1 helix adjusts the pore size, which is then fine-tuned by the N-terminal helix.
Two cryo-electron-microscopy images of the histone chaperone FACT interacting with components of nucleosomes shed light on how FACT manipulates nucleosomes to promote transcription, DNA repair and DNA replication.
Models compiled from subduction zones worldwide show that the elastic properties of the rock overlying shallow subduction megathrusts can be used to estimate potential slip, possibly enabling early tsunami warnings.
Individual cobalt phthalocyanine derivative molecules immobilized on carbon nanotubes effectively catalyse the electroreduction of CO2 to methanol via a domino process with high activity and selectivity and stable performance.
Cardiac stem cell therapy in mouse models of ischaemia–reperfusion injury demonstrates that improvement in heart function is linked to an immune response characterized by the induction of CCR2+ and CX3CR1+ macrophages.
Recordings from 30,000 neurons in 42 brain regions are used to delineate the spatial distribution of neuronal activity underlying vision, choice, action and behavioural engagement in mice.
Radial-velocity measurements of a Galactic B-type star show a dark companion that seems to be a black hole of about 68 solar masses, in a widely spaced binary system.
Cells that populate scar tissue in mammalian skin migrate to wounds as prefabricated matrix from the subcutaneous fascia, including embedded blood vessels, macrophages and peripheral nerves.
The mammalian middle ear is thought to have evolved independently several times, and a specimen of the new species Jeholbaatar kielanae provides support for the idea, with evolution of the chewing apparatus perhaps driving migration of the auditory bones.
Analysis of the dynamics of chromosome reorganization after exit from mitosis reveals the distinct but mutually influential forces that drive chromatin reconfiguration.
Screening of a library of bile acid metabolites revealed two derivatives of lithocholic acid that act as regulators of T helper cells that express IL-17a and regulatory T cells, thus influencing host immune responses.
Since the 1980s, rapid warming of the Indo-Pacific warm pool has altered global rainfall pattern by changing the residence time of the Madden–Julian Oscillation, decreasing it by 3–4 days over the Indian Ocean and increasing it over the Indo-Pacific by 5–6 days.
A method of engineering efficient and stable InP/ZnSe/ZnS quantum dot light-emitting diodes (QD-LEDs) has improved their performance to the level of state-of-the-art cadmium-containing QD-LEDs, removing the problem of the toxicity of cadmium in large-panel displays.
MLLT3 is identified as a crucial regulator of the self-renewal of human haematopoietic stem cells, and helps to maintain an active chromatin state in haematopoietic stem-cell regulatory genes during culture.
Efficient lasing from two transition-metal dichalcogenide layers is engineered by exploiting the excitonic states that emerge when the layers are placed together to form a heterostructure.