Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A probabilistic computer utilizing probabilistic bits, or p-bits, is implemented with stochastic nanomagnetic devices in a neural-network-inspired electrical circuit operating at room temperature and demonstrates integer factorization up to 945.
Circadian circuits, entrained by light and tuned by the brain, regulate intestinal group 3 innate lymphoid cells in mice, along with epithelial reactivity, microbiome composition and lipid metabolism.
Single-molecule dynamics reveal that the GTPase activity of eukaryotic initiation factor eIF5B serves as a kinetic checkpoint for the transition from translation initiation to elongation.
Wilderness areas with minimal levels of human disturbance promote the persistence of biodiversity by acting as buffers against species loss, and therefore represent key targets for environmental protection.
Scenarios that model a realistic phase-out of fossil fuels find no substantial near-term increase in the rate of warming, and suggest benefits for climate change mitigation and air quality at essentially all timescales.
Structural and biophysical studies reveal that low-barrier hydrogen bonds enable long-range communication between the active sites of multimeric enzymes and synchronise catalysis.
Restoring the function of p53 in a mouse model of pancreatic ductal adenocarcinoma leads to the accumulation of α-ketoglutarate, which increases levels of the 5-hydroxymethylcytosine chromatin modification and results in reduced tumour-cell fitness.
Observations and regional climate models show that the increasing coverage of ice slabs on the Greenland ice sheet could lead to a global sea-level rise of up to 74 millimetres by 2100.
A statistical forecast model using a deep-learning approach produces useful forecasts of El Niño/Southern Oscillation events with lead times of up to one and a half years.
Delivery via caesarean section, maternal antibiotic prophylaxis and colonization by opportunistic pathogens associated with the hospital environment affect the composition of the gut microbiota of children from birth until infancy.
A global dataset of river longitudinal profiles shows that river profiles become straighter with increasing aridity and numerical modelling suggests that this can be explained by rainfall–runoff regimes in different climate zones.
Mollisonia plenovenatrix, a small predatory arthropod from the Burgess Shale dated to about 508 million years ago, is morphologically close to horseshoe crabs, which suggests chelicerates arose as micropredators early during the Cambrian explosion.
The RNA helicase DDX3X has a critical role in regulating both the induction of stress granules and the activation of the NLRP3 inflammasome in cells under stress conditions.
Galaxy GSN 069 has unprecedented eruptions of X-ray light every nine hours, which indicate fast transitions between cold and warm states and may shed light on black hole accretion.
Landmarks of early stages of human embryogenesis can be recapitulated in a highly controllable and scalable fashion by culturing human pluripotent stem cells in a microfluidic device.
Excitation to the second excited state of 229Th is used to populate the metastable state 229mTh, enabling accurate determination of the isomer’s energy, half-life and excitation linewidth.
The transition energy of the first excited state of 229Th to the ground state is determined through the measurement of internal conversion electrons to correspond to a wavelength of 149.7 ± 3.1 nanometres.