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The density and size of contact gradients between the endoplasmic reticulum and the plasma membrane control the speed and direction of cell migration by restricting receptor signalling to the front.
Genomic analysis of Plasmodium DNA from 36 ancient individuals provides insight into the global distribution and spread of malaria-causing species during around 5,500 years of human history.
Subsets of ILC3s upregulate the immunoregulatory checkpoint molecule CTLA-4 after stimulation in a microbiota-dependent manner, and advances to support CTLA-4+ ILC3s may represent a treatment opportunity in IL-23-driven chronic inflammation.
An investigation of the subpectoral diverticulum—an inflatable air sac structure between the major flight muscles—in 68 avian species reveals that the respiratory system has a role in the mechanics of flight in soaring birds.
A DNA sequencing method with single-molecule fidelity detects mismatches and damage present in only one of the two DNA strands with patterns that are both similar and distinct compared to known mutation patterns.
The Great Oxidation Event represents a tipping point in Earth’s O2 mass balance—when more O2 was being produced than destroyed—that forever changed the habitability of worldwide oceans.
Focusing on the role of external forcing, an investigation of the causes of observed changes in the tropical Pacific surface warming pattern over recent decades discusses a possible shift in the drivers of this pattern.
We present genome-wide data from 64 subadults interred in Chichén Itzá around ad 500–900 that gives insight into burial rituals, and shows that their genomic legacy is still present and has adapted to immune challenges post-1492.
How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.
Molecular-level experiments are described to develop a detailed assessment of 11 new particle formation mechanisms in a global climate model and, in comparison with simulations and observations, the dominant mechanisms worldwide are mapped.
A tyrosine tripeptide was discovered to unexpectedly form a supramolecular amorphous glassy material by constructing a non-specific hydrogen bonding network with structural water molecules.
A learning-in-simulation framework for wearable robots uses dynamics-aware musculoskeletal and exoskeleton models and data-driven reinforcement learning to bridge the gap between simulation and reality without human experiments to assist versatile activities.
The charge-density-wave state in RbV3Sb5 can be optically manipulated by applying linearly polarized light along high-symmetry directions, which demonstrates the potential of light as a control knob to manipulate complex quantum phenomena in correlated materials.
A study of neuronal activity in rats finds that sleep loss adversely affects hippocampal function and memory by dissociating hippocampal sharp-wave ripples from memory replay and reactivation events.
A trial investigating the effects of a hybrid working schedule in a Chinese technology firm in 2021–2022 shows that working from home two days a week improved job satisfaction, reduced quitting and did not affect performance.
A large-scale meta-analysis across eight biobank datasets identifies common genetic variants associated with mosaic loss of the X chromosome in female participants.
We have implemented a two-site Kitaev chain in a two-dimensional electron gas by coupling quantum dots through Andreev bound states in a superconductor–semiconductor hybrid region.
A study demonstrates that metabolic signalling and inflammatory cues associated with obesity selectively induce expression of PD-1 on tumour-associated macrophages to suppress anti-tumour immunity.
Measurements of activity in the entorhinal cortex of monkeys indicate that the recruitment of a cognitive map is a key part of mental navigation, and that cognitive maps can support behavior in the absence of external sensory input.
Matching seismic waveforms show that the inner core of Earth gradually super-rotated from 2003 to 2008, and then more slowly sub-rotated from 2008 to 2023 back through the same path.
