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Anion recognition in competitive, aqueous media remains a critical challenge. Bulk and local solvation models for anion recognition events are herein explored, as well as targeted design approaches to retain strong anion binding in highly polar media.
JWST collects vast amounts of information about exoplanets light years away from Earth. Back home, the measured optical constants of laboratory aerosols are critically input parameters in models to interpret the observational results.
Gold catalysts have attracted attention for their ability to activate hydrogen towards the hydrogenation of organic molecules. This Review explores strategies to enhance hydrogen–gold interactions to help design new efficient hydrogenation catalysts.
Electrochemical devices enable clean energy technologies such as hydrogen cells, batteries and solar fuels. Their design is hindered by incomplete information about the electrochemical interface during operation. Complementary optoelectronic probes offer a path to improved mechanistic insights into such interfaces.
The unique properties of selenium have been exploited in protein science. This Review highlights the recent applications of selenium chemistry in protein chemical synthesis, modification, folding, stabilization, the preparation of therapeutic proteins and more.
DNA has emerged as an attractive substrate for molecular information processing. This Review explores the application of DNA for computing and data storage, as well as the route to integrate these fields.
This Review introduces solar reforming as an emerging technology to produce sustainable fuels and chemicals from diverse waste feedstocks using sunlight. The chemistry and concept of solar reforming, suggestions of key metrics and proposed directions to realize solar-powered refineries for a future circular economy are discussed.
This Review highlights the strategies and challenges for targeting RNA with small molecules in medicinal chemistry. It emphasizes their potential as drugs and tools for understanding complex biological processes while encouraging chemists to contribute to this field for future advances.
Performing logical operations with molecular excitons may provide opportunities for developing ultrafast, subnanometre and biocompatible computational architectures. This Roadmap outlines a framework for using multiexcitonic processes such as singlet fission and triplet–triplet annihilation to drive logical devices.
Lytic polysaccharide monooxygenases are key enzymes in biomass processing and pathogenicity. They are, to our knowledge, the first known copper enzymes capable of utilizing H2O2 to hydroxylate C–H bonds. This Review draws a portrait of the catalytic paths at play and highlights outstanding questions in their reactivity.
Thirty-four years ago, Curry and Rumelhart described a neural network-based approach to annotate tandem mass spectra. Their ideas foreshadowed several important developments in computational mass spectrometry over the past decade, but many of the challenges they discuss remain relevant today.
The total biosynthesis and engineering of complex natural products is now routinely achieved in filamentous fungal host organisms. This technology offers substantial advantages over traditional total chemical synthesis for the production of both known and new specialized metabolites.
