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  • The COVID-19 pandemic has stretched healthcare resources and caused severe knock-on effects on patients with metabolic diseases worldwide. We encourage clinicians and patient-interest groups in the field of diabetes and metabolism to raise their voices to ensure adequate care and admission of patients.

    • Stefan R. Bornstein
    • Francesco Rubino
    • Geltrude Mingrone
    Comment
  • The prevalence of COVID-19-associated diabetes is not the result of a single event but of a combination of disease susceptibility associated with chronic illness and COVID-19-specific mechanisms affecting metabolism. Whether a separate entity of post-COVID-19 diabetes, possibly associated with lasting β-cell damage, also exists is not yet clear.

    • Domenico Accili
    Comment
  • Cell culture media are typically selected on the basis of common laboratory practices but have major effects on the validity, reproducibility and physiological relevance of the scientific findings. We provide arguments and quantitative examples of why choosing an appropriate cell culture medium matters, particularly in metabolic studies.

    • Shoval Lagziel
    • Eyal Gottlieb
    • Tomer Shlomi
    Comment
  • Individual differences in physical performance in the sedentary state and in response to exercise training have been observed in rodent and human studies. The genomic variants underlying these genetic components are unknown. Nonetheless, without a rich genetic endowment, world-class athletic performance is out of reach.

    • Mark A. Sarzynski
    • Claude Bouchard
    Comment
  • As the metabolism community has grown and diversified with scientists from multidisciplinary backgrounds, metabolic terminology has evolved and expanded. In this Comment, we reflect on this new vernacular and how established terminology can guide future discussions of metabolic research.

    • Mary-Ellen Harper
    • Mary-Elizabeth Patti
    Comment
  • We are approaching the 100th anniversary of Otto Warburg’s first description of the metabolic phenotype bearing his name—a propensity for tumours to metabolize glucose anaerobically rather than aerobically, even when oxygen is available. Generations of scientists have studied the Warburg effect, yet misconceptions persist about its causes and relationship to oxidative metabolism in the mitochondria. Here, we review the definition of the Warburg effect and discuss its place within a modern understanding of cancer biology.

    • Ralph J. DeBerardinis
    • Navdeep S. Chandel
    Comment
  • Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease worldwide, mainly because of the massive parallel global increase in obesity. Extensive public-health and political efforts will be needed in the near future to counteract this disturbing development.

    • Anna Mae Diehl
    • Nathalie J. Farpour-Lambert
    • Herbert Tilg
    Comment
  • Mammalian cell culture represents a cornerstone of modern biomedical research. There is growing appreciation that the media conditions in which cells are cultured can profoundly influence the observed biology and reproducibility. Here, we consider a key but often ignored variable, oxygen, and review why being mindful of this environmental parameter is so important in the design and interpretation of cell culture studies.

    • Tslil Ast
    • Vamsi K. Mootha
    Comment
  • Modern mass spectrometric technologies provide quantitative readouts for a wide variety of lipid specimens. However, many studies do not report absolute lipid concentrations and differ vastly in methodologies, workflows and data presentation. Therefore, we encourage researchers to engage with the Lipidomics Standards Initiative to develop common standards for minimum acceptable data quality and reporting for lipidomics data, to take lipidomics research to the next level.

    • Gerhard Liebisch
    • Robert Ahrends
    • Kim Ekroos
    Comment
  • Over the past decade, the field of metabolism has witnessed remarkable scientific discoveries that reshaped the understanding of metabolic physiology and disease. As we launch Nature Metabolism, we look at what the future holds for metabolic research.

    • Fredrik Bäckhed
    • Elisabetta Bugianesi
    • Matthias Tschöp
    Comment
  • Many commonly used inbred mouse strains carry random mutations that can affect the results of metabolic studies. Yet, awareness of such mutations as a source for experimental variation and seemingly contradictory results is lacking. It is time that scientists pay more attention to the identification, tracking and accurate reporting of mouse strains used in experiments.

    • José Antonio Enríquez
    Comment