Perspectives

Fernandez-Patron et al. propose a unifying framework explaining how diverse risk factors such as hypertension, obesity and diabetes lead pathogenesis and progression of heart failure.

Human pluripotent stem cells have been shown to be important models for interrogating the molecular basis for heart disease. This review highlights the contributions of these models to our understanding of inherited arrhythmia syndromes, with a focus on integrating mechanistic and genome-wide association study data.

Based on the 19th Global Cardiovascular Clinical Trialists meeting, this Perspective discusses potential sources of evidence that may be used to complement explanatory phase 3 randomized clinical trials and accelerate the development of new cardiovascular medications.

Barisano et al. discuss how vascular dysfunction caused by blood–brain barrier breakdown interacts with amyloid beta and tau AD biomarkers and may predict early cognitive impairment, dementia and Alzheimer’s disease.