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The advent of EGFR inhibitors has been a game changer in clinical oncology. However, differing sensitivity to different mutations, resistance and adverse effects continue to impede decisive treatment of mutant EGFR–driven cancers, which highlights the need for advanced and innovative EGFR-targeting approaches.
A deeper understanding of the specific tumor context and microenvironment, the underlying tumor immunology, and barriers to effective treatment, including therapy resistance and adverse effects, is essential to the development of improved immunotherapy modalities and regimens.
Robust and faithful preclinical models are essential for understanding the underlying biology of human cancer and for devising new and improved therapies.
A deeper understanding of the molecular and cellular underpinnings of metastatic disease and a renewed focus on metastasis-targeting therapeutic approaches raise hopes for improved clinical translation.
In our Focus on 2021 in Review, the Nature Cancer team and leading experts look back at the biggest developments for the cancer field over the past 12 months.
What happens to a manuscript after submission? How does the editor reach a decision? What is the editor’s role during peer review? We take a look into the editorial process at Nature Cancer.
The Biden administration has proposed a new agency to drive innovation in health research, including cancer. The focus on cancer and accelerated development is welcome, but for the time being, whether and how these plans will materialize is less clear.
Social media have emerged as a key communication tool for scientists. Here we explore how to reap the benefits and avoid the pitfalls of social networking.
Making data available is essential for validating and furthering scientific discoveries. Helping authors navigate whether, how and in what form to share the data is also essential.
The COVID-19 pandemic is proving a major setback for achieving gender equality. Post-pandemic recovery efforts must focus on supporting diversity and bridging the gender gap.
Cancer therapies have evolved considerably in recent decades, substantially improving the quality of life and survival of patients with cancer. In this issue, we launch our Series on Cancer Therapy, exploring current paradigms and recent advances and challenges in this field, through specially commissioned articles.
The election of Joe Biden to the US presidency has rekindled optimism in the world of science. To truly bring science to center stage will require bold political moves, the pulling together of all stakeholders, and time.
This month marks one year since the launch of Nature Cancer. As we celebrate our first anniversary, we reflect on the past year and thank the cancer research community for embracing our journal.
As COVID-19 continues to surge, it is essential to understand and address the looming crisis of mental-health issues caused or exacerbated by the pandemic.
Postdoctoral researchers face substantial challenges and stresses that have been exacerbated by the COVID-19 pandemic. Positive action is needed from research institutions, funders and individual investigators to support postdocs and fortify the research endeavor.
The need to address COVID-19 is placing huge demands on biomedical research and regulatory processes. Under pressure, it is essential to uphold high bioethical principles and rigorous standards for the development and approval of medicines.
