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A non-invasive biomarker of the degree of collective order of monolayers of corneal endothelial cells cultured for transplantation predicts the long-term prognosis of corneal restoration in patients.
The simultaneous removal of endogenous T-cell receptor α-chains and β-chains, and the orthotopic placement of an exogenous receptor in human T cells via CRISPR gene-editing, prevents the mispairing between endogenous and transgenic receptors while preserving the cells’ function.
In injured intervertebral discs, disruptions in fibre organization and in cellular contractility result in a fibrotic phenotype and progressive tissue degeneration.
A data-clustering method that incorporates prior knowledge of biological context reveals prognostic signatures of proteomic expression in patients with acute myeloid leukaemia.
This Perspective summarizes the most recent developments in the bioprinting of cartilage, bone and skin for clinical applications, and discusses translational challenges and opportunities in the fabrication of complex 3D-printed tissues and organs.
Computationally designed antibody–drug conjugates easily self-assemble via affinity ligands that non-covalently link a therapeutic drug to conserved sites on native IgG antibodies.
Applying motion correction to standard foetal magnetic resonance imaging via image-registration techniques improves the diagnostic evaluation of cardiovascular structures in foetuses.
A deep-learning model for cancer detection trained on a large number of scanned pathology slides and associated diagnosis labels enables model development without the need for pixel-level annotations.
Haematopoietic stem and progenitor cells, edited via CRISPR to mimic mutations ameliorating sickle-cell disease, engraft when transplanted in macaques and maintain foetal haemoglobin in circulation.
For genome-wide screens and other applications that require the processing of a large number of cells, the immunomagnetic sorting of cells on a microfluidic chip is a scalable, rapid and cost-efficient alternative to fluorescence-activated cell sorting.
Encapsulation of the therapeutic monoclonal antibody rituximab, and its molecular targeting to brain metastases of B-cell lymphoma, significantly boosts the antibody’s therapeutic effectiveness in mice.
A suite of microelectrodes integrated into glass pipettes, for the simultaneous recording of intracellular and extracellular data in the brains of living mice and rats, yields ground-truth data for the validation of the performance of spike-sorting algorithms.
Drug-loaded nanoparticles that specifically bind to phages infecting cancer-promoting bacteria found in colonic tumours augment the effects of chemotherapy against colorectal cancer in mice.
This Perspective overviews immunotherapies leveraging engineering approaches, including the design of biomaterials, delivery strategies and nanotechnology solutions, for the realization of individualized cancer treatments.