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Mesenchymal stromal cells with their nuclei removed by density-gradient centrifugation and displaying chemoattractant receptors and endothelial-cell-binding molecules function as effective vehicles for the delivery of therapeutics to diseased tissue.
An organic electrolytic photocapacitor transducing deep-red light into electrical signals and implanted within a thin cuff around the sciatic nerve of rats allows for wireless electrical stimulation of the nerve for over 100 days.
Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy.
Strain maps of cardiomyocyte nuclei during contraction indicate that, by integrating environmental mechanical cues, the nuclei of cardiomyocytes stabilize the fate of cells through the reorganization of epigenetically marked chromatin.
The integration of scalable and modular hardware and software for the remote operation of programmable miniaturized wireless networks allows for the study of the behaviour of large groups of rodents.
A silk-fibroin hydrogel converts rat quiescent ventricular cardiomyocytes into pacemaker cardiomyocytes by inducing the ectopic expression of the vascular endothelial cell-adhesion glycoprotein cadherin.
A generative model that learns mappings between hand kinematics and the associated neural spike trains can be rapidly adapted to new sessions or participants by using limited additional neural data.
Early apoptotic responses to oncolytic virotherapy in mice can be rapidly detected by chemical-exchange-saturation-transfer magnetic resonance fingerprinting, by leveraging a neural network trained with simulated magnetic resonance fingerprints.
Antitumour immune responses to checkpoint blockade can be augmented by modulating the microbiota in the tumour with hydrogel-embedded silver nanoparticles and specific exogenous bacteria, as shown for mice with squamous carcinoma tumours.
The human proteome can be algorithmically mined to identify thousands of encrypted peptides, encoded in proteins with biological function unrelated to the immune system, that display antibacterial activity in vivo.
A bispecific antibody targeting the T-cell co-receptor CD3ε and the immune checkpoint programmed-death ligand 1 on dendritic cells rejuvenates tumour-specific CD8 T cells, leading to durable antitumour responses in murine models of cancer.
Epigenetic inhibitors that promote antigen presentation and potentiate T-cell-mediated cytotoxicity can be identified by a high-throughput screen of cytotoxic T-cell activity in breast tumour organoids.
The concurrent depletion of tumour cells and immunosuppressive cells via a monoclonal antibody targeting a common surface marker prevents tumours from acquiring resistance to therapies involving immune checkpoint blockade.
Closed-loop electrical stimulation of the internal capsule of participants undergoing intracranial epilepsy monitoring improved the participants’ performance on a cognitive conflict task, and performance could be decoded from electrode activity.
Efficacious cancer vaccines can be made via the cryogenic silicification of tumour cells followed by the decoration of the silicified surface with pathogen-associated molecular patterns.
Multifilament surgical sutures functionalized with a conductive polymer and incorporating pledgets with capacitive sensors operated via radiofrequency identification can be used to monitor physicochemical states of deep surgical sites.
Monoclonal antibodies conjugated with multiple polymer chains functionalized to target glucose transporter 1 and detaching in the reductive tumour microenvironment augment the potency and safety of checkpoint blockade therapy for glioblastoma.
Lipid nanoparticles can be optimized for the efficient delivery of therapeutic mRNAs to the lung via nebulization, as shown for the delivery of a therapeutic antibody in mice challenged with a lethal dose of the H1N1 influenza A virus.
Orally delivered nanocarriers of insulin or rapamycin made from a polymeric bile acid exert metabolic and immunomodulatory functions, restore blood-glucose levels in mice and pigs with type 1 diabetes, and delay the onset of diabetes in mice.
The loading of two different protein therapeutics onto extracellular vesicles can be optimized by genetically engineering the parent cells, as shown for extracellular vesicles displaying decoy receptors for two pro-inflammatory cytokines.