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Human:pig embryos can be produced by deleting the MYF5, MYOD and MYF6 genes in pig embryos via CRISPR and somatic-cell nuclear transfer, followed by the delivery of TP53-null human induced pluripotent stem cells via blastocyst complementation.
Mouse skeletal muscle can be regenerated using a small-molecule cocktail that activates resident satellite cells in situ and by myogenic stem cells selectively induced and expanded from dermal or skeletal muscle when the cocktail is used in vitro.
Ultrafast ultrasound localization microscopy of intravenously injected microbubbles enables transcranial imaging of deep vasculature in the adult human brain at microscopic resolution and the quantification of haemodynamic parameters.
A computational method leveraging deep learning and molecular dynamics simulations enables the rapid discovery of antimicrobial peptides with low toxicity and with high potency against diverse Gram-positive and Gram-negative pathogens.
A dysfunctional TRPV4–GSK3β pathway in osteoarthritic chondrocytes renders the cells unable to respond to viscoelastic changes in the extracellular matrix.
A renally clearable nanoparticle consisting of a polysaccharide core and an amorphous-like iron oxide shell generates strong T1 MRI contrast, facilitating the imaging of microvessels, as shown in rodents and rabbits.
A data-efficient and interpretable deep-learning method for the multi-class classification of whole-slide images that relies only on slide-level labels is applied to the detection of lymph node metastasis and to cancer subtyping.
A skin-worn device that simultaneously monitors blood pressure and heart rate via ultrasonic transducers and multiple biomarkers via electrochemical sensors captures physiological effects of food intake and exercise in human volunteers.
A polyvalent STING agonist prolongs the activation of innate-immunity pathways through the formation of STING condensates, and leads to synergistic therapeutic outcomes in vivo when combined with the STING ligand cGAMP.
A deep learning model trained on raw pixel data in hundreds of thousands of echocardiographic videos for the prediction of one-year all-cause mortality outperforms clinical scores and improves predictions by cardiologists.
Input–output models can predict multiregional brain network dynamics in response to temporally varying patterns of ongoing direct electrical stimulation, with variabilities in prediction accuracy explained by at-rest functional connectivity.
A neuroprosthetic interface comprising a muscle actuator coupled to a natively pedicled skin flap in a cuff-like architecture elicits graded contact and vibratory afferent signals analogous to those elicited by mechanical stimulation of intact skin.
The adsorption of coagulation factors on microspheres placed within extracorporeal blood-purification devices allows for transient blood thinning and faster recovery of haemostasis.
Cytidine base editors delivered to the liver of mice with phenylketonuria via adeno-associated viruses or lipid nanoparticles do not lead to detectable off-target edits in the RNA and DNA of hepatocytes.
A microneedle patch that samples and quantifies target protein biomarkers in interstitial fluid allows for longitudinal monitoring of the levels of a range of disease-relevant biomarkers, as shown in live mice.
Human mesenchymal stem cells can be mechanically and pharmacologically conditioned to enhance vascular regeneration in vivo, as shown in mice with hindlimb ischaemia.
Mimicking the molecular architecture of channel-forming membrane proteins of a target microbe can be used to design host defence peptides that specifically target a particular pathogen, as shown here for Mycobacterium tuberculosis.
Lentiviruses co-packaging SpCas9 mRNA and an expression cassette encoding for a guide RNA targeting the Vegfa gene prevent mice from developing wet age-related macular degeneration induced by Vegfa. [Summary amended to correct the description of the packaged cargo.]