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A multiple-instance-learning model trained to encode and aggregate either the local sequence contexts or the genomic positions of somatic mutations achieved best-in-class performance in classification and prediction tasks.
An intravenous needle that is sufficiently stiff for insertion into soft tissue yet becomes irreversibly flexible after insertion offers similar fluid-delivery performance and causes less inflammation than commercial devices for intravenous access.
A biodegradable zwitterionic gel covering the tip end of commercial catheters for the continuous and subcutaneous infusion of insulin extends the longevity of the catheters and improves the rate of insulin absorption in diabetic mice and minipigs.
Cas13 can intrinsically target host RNA in mammalian cells through previously unrecognized mechanisms without the involvement of a CRISPR RNA, and host genes involved in viral processes can constrain the lentiviral delivery and expression of Cas13.
Degradable polymeric porous microcapsules loaded with exosomes from mesenchymal stem cells or regulatory T cells led to the restoration of retinal thickness in mice with retinal ischaemia-reperfusion injury and to reductions in inflammatory cells in monkeys with mycobacterial uveitis.
The temporary opening of the blood–brain barrier via focused ultrasound triggers the recruitment of central nervous system-associated macrophages and the proliferation of microglia, as well as population size increases in disease-associated microglia.
The shift in fluorescence lifetime of tumour tissue with respect to normal tissue after systemic injection of the near-infrared dye indocyanine green can be used to distinguish tumour tissue from normal tissue with high accuracy.
Laminin-coated branched electronic scaffolds injected into hydrogel-filled lesions and spanning deeper regions in the brains of mice promote and track the migration of host brain cells into the lesions.
A high-throughput method leveraging the Illumina HiSeq platform to screen in the order of 108 individual antibody–antigen interactions within 3 days facilitates the rapid discovery of antibodies to clinically relevant targets.
The tumour-targeting activity and specificity of T cells with a CAR forming a reversible covalent bond with a hapten can be regulated by a small-molecule adapter that selectively binds to the hapten and to a chosen tumour antigen.
Synchronized chest and peripheral skin sensors for the monitoring of vascular resistance, cardiac output and other metrics of cardiovascular health allow for the classification of haemodynamic states resulting from exposure to stressors.
An in-ear integrated array of sensors for electroencephalography, electrooculography and electrodermal activity and for lactate can be used to concurrently monitor brain states and lactate levels in sweat.
A computationally designed antigen based on the receptor binding domain of the spike protein of sarbecoviruses elicits broad humoral responses against severe acute respiratory syndrome viruses in mice, rabbits and guinea pigs.
Elevated extrinsic tissue-scale forces can drive pathological foreign-body responses to implants, mediated by the Rac2-mediated activation of a subpopulation of mechanoresponsive myeloid cells.
A portable multiplexed assay allows for the rapid detection, via plasmonic-gold-enhanced near-infrared fluorescence, of SARS-CoV-2 RNA at single-copy sensitivity and single-nucleotide specificity for the discrimination of variants of the virus.
A subcutaneously injected hydrogel conjugated with antibodies for interleukin-6 substantially reduces the levels of the cytokine during chimaeric antigen receptor T-cell therapy while maintaining its antitumour efficacy.
Adjuvanting the lipid and the encapsulated messenger RNA-encoded antigen in lipid-nanoparticle mRNA vaccines can enhance the efficiency of mRNA delivery and the activation of the immune responses, as shown for a COVID-19 vaccine in mice.
Established antigen-specific T-cell responses can be suppressed by conjugating the antigen to a glycosylated polymer, as shown in a mouse model of multiple sclerosis and with the suppression of responses to vaccination in non-human primates.
Interpretable machine-learning models can identify clinical-stage monoclonal antibodies with optimal combinations of low off-target binding and low self-association in physiological and antibody-formulation conditions.
A cell-barcoding method leveraging ubiquitous promoters to express small-RNA barcodes modified with direct-capture sequences allows for the longitudinal tracking of the transcriptional states of CAR T cells infused in a mouse model of leukaemia.