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The assessment of the performance of molecular assays would benefit from quantifying the resolution of molecular concentration — a new metric that we propose and evaluate here.
A deeper understanding of the myriad ways that the mechanics of cellular and tissue microenvironments trigger or exacerbate disease will open up pathways for new interventions.
In biomedical studies, the environmental conditions used in mammalian cell culture are often underreported, and are seldom monitored or controlled. Best-practice standards are urgently needed.
The proposal for an Advanced Research Projects Agency for Health (ARPA-H) being considered by the United States Congress is bold and necessary, yet will require unrelenting focus, independence and a measured risk-taking culture.
The proliferation of synthetic data in artificial intelligence for medicine and healthcare raises concerns about the vulnerabilities of the software and the challenges of current policy.
The effectiveness of cancer immunotherapies will benefit from a range of strategies — new, or borrowed from other classes of therapeutic — to trigger durable immune responses.
The availability of higher-quality biomedical and clinical data is widening the reach and usefulness of data-fitted biophysical models and of data-driven mathematical and statistical modelling.
To facilitate diagnostic radiology at the point of care, improvements in imaging hardware and processing software that raise the signal away from the noise floor are being leveraged toward improving device portability or accessibility.
The preclinical performance of subretinal or intracorneal delivery of Cas9 nucleases encoded in RNA foreshadows safer and effective one-and-done gene therapies for eye diseases.