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The assessment of the performance of molecular assays would benefit from quantifying the resolution of molecular concentration — a new metric that we propose and evaluate here.
Mesenchymal stromal cells with their nuclei removed by density-gradient centrifugation and displaying chemoattractant receptors and endothelial-cell-binding molecules function as effective vehicles for the delivery of therapeutics to diseased tissue.
An organic electrolytic photocapacitor transducing deep-red light into electrical signals and implanted within a thin cuff around the sciatic nerve of rats allows for wireless electrical stimulation of the nerve for over 100 days.
A deeper understanding of the myriad ways that the mechanics of cellular and tissue microenvironments trigger or exacerbate disease will open up pathways for new interventions.
Cancer cells enriched in cholesterol in their plasma membrane impair T-cell-mediated cytotoxicity, which can be augmented by stiffening the cancer cells via cholesterol depletion, as shown in mouse models of adoptive T-cell immunotherapy.
Strain maps of cardiomyocyte nuclei during contraction indicate that, by integrating environmental mechanical cues, the nuclei of cardiomyocytes stabilize the fate of cells through the reorganization of epigenetically marked chromatin.
The integration of scalable and modular hardware and software for the remote operation of programmable miniaturized wireless networks allows for the study of the behaviour of large groups of rodents.
A silk-fibroin hydrogel converts rat quiescent ventricular cardiomyocytes into pacemaker cardiomyocytes by inducing the ectopic expression of the vascular endothelial cell-adhesion glycoprotein cadherin.
A generative model that learns mappings between hand kinematics and the associated neural spike trains can be rapidly adapted to new sessions or participants by using limited additional neural data.
The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.
Early apoptotic responses to oncolytic virotherapy in mice can be rapidly detected by chemical-exchange-saturation-transfer magnetic resonance fingerprinting, by leveraging a neural network trained with simulated magnetic resonance fingerprints.
Antitumour immune responses to checkpoint blockade can be augmented by modulating the microbiota in the tumour with hydrogel-embedded silver nanoparticles and specific exogenous bacteria, as shown for mice with squamous carcinoma tumours.
This Perspective describes the ecosystem of software available for the analysis of tissue images and discusses the need for interactive online guides that help histopathologists make complex images understandable to non-specialists.
This Perspective describes current clinical standards for intraoperative tissue analysis in oncology and discusses potential clinical implementations of intraoperative imaging for pathology-assisted surgery.
The human proteome can be algorithmically mined to identify thousands of encrypted peptides, encoded in proteins with biological function unrelated to the immune system, that display antibacterial activity in vivo.
A bispecific antibody targeting the T-cell co-receptor CD3ε and the immune checkpoint programmed-death ligand 1 on dendritic cells rejuvenates tumour-specific CD8 T cells, leading to durable antitumour responses in murine models of cancer.
Epigenetic inhibitors that promote antigen presentation and potentiate T-cell-mediated cytotoxicity can be identified by a high-throughput screen of cytotoxic T-cell activity in breast tumour organoids.