Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
An assay leveraging strand-displacement reactions and enzymatic amplification for the recognition of viral RNA and implemented on origami paper allows for the fast colorimetric detection of SARS-CoV-2 variants, with single-nucleotide specificity.
Assays leveraging the CRISPR-associated enzyme Cas13 and isothermal RNA amplification for the detection of viral RNA are being simplified for point-of-care use.
Weakly supervised deep-learning models for the analysis of whole-slide images from tumour biopsies perform better at prognostic tasks if the models incorporate context from the local microenvironment.
An adhesive hydrogel patch made from off-the-shelf materials seals and aids the healing of gastrointestinal-tissue defects without the need for sutures, as shown with the repair of gastrointestinal leaks in live rats and pigs.
Arrays of ultrasonic transducers arranged hemispherically around the head enable the mapping of haemodynamic changes in the brain via photoacoustic computed tomography at resolutions down to 350 micrometres and 2 seconds.
Volumetric histological imaging of mouse and human tissues without the need for tissue staining or excision can be performed in real time via microscopes leveraging confocally aligned light-sheet illumination.
Deep-learning models trained with images of the external part of the eyes, rather than fundus images of the retina, can also be used to detect severe diabetic conditions, such as diabetic retinopathy.
Freeze-dried genetic circuits can be integrated with textiles for the detection — colorimetric, or via fluorescence or luminescence — of small molecules and nucleic acids from SARS-CoV-2 and other pathogens.
Off-target genome editing in the liver can be reduced by using lipid nanoparticles to deliver oligonucleotides that disrupt the secondary structure of single-guide RNAs as well as short interfering RNAs targeting Cas9 mRNA.
An electromechanical chip consisting of self-assembled DNA-based cantilevers immobilized on a liquid-gated graphene field-effect transistor can be configured to rapidly detect ultra-low concentrations of biomolecules, including viral nucleic acids, in biological fluids.
Coating mesenchymal stromal cells with a soft gel incorporating specific chemomechanical cues that enhance the production of collagenases enhances the ability of the cells to inhibit aberrant tissue remodelling in mice with fibrotic lungs.
Flagellated bacteria coated with antigen-adsorbing nanoparticles and injected into irradiated tumours elicit systemic antitumour immune responses by transporting tumour antigens towards the tumour periphery, where they are taken up by functional antigen-presenting cells.
The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.
Deep surgical wounds can be monitored via conductive multifilament surgical sutures incorporating ‘sensing pledgets’ bearing capacitive sensors operated via harmonic radiofrequency identification.
A microwell chip facilitates the differentiation of aggregates of human induced pluripotent stem cells into pancreatic-duct-like organoids and the characterization of the differentiation process at the single-cell level.
The elastic modulus of the superficial and deep layers of the skin can be dynamically measured via wearable conformal electromagnetic devices consisting of a vibratory actuator and a soft strain-sensing sheet.
Organic electrochemical transistors functionalized with antigen-specific nanobodies can rapidly and specifically detect antigens at attomolar-to-nanomolar levels in bodily fluids.
An efficient protocol for the preparation of DNA libraries for the analysis of methylation patterns in cell-free DNA in plasma enhances the sensitivity of bisulfite sequencing for the early detection of lung cancer.
