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Wearable piezoelectric thin films integrated with multiphysics modelling and three-dimensional digital image correlation can decode facial expressions in real time.
Narrow-bandwidth signals and relaxed neural-recording parameters can substantially reduce the power requirements of brain–machine interfaces without degrading their performance.
Microwell arrays enable the culture of thousands of organoids with increased homogeneity, and facilitate high-content image-based analyses and high-throughput drug screens.
The oral delivery of a microencapsulated bacterial cocktail into animal models of kidney disease promotes the degradation of nitrogenous waste in the gut, thereby supporting renal function.
Positron emission tomography enables the tracking, in a mouse, of an intravenously injected cell radiolabelled with mesoporous silica nanoparticles containing 68Ga.
Lipofuscin, an endogenous pigment, can be used as a near-infrared fluorescent biomarker to stage and to monitor the progression of chronic liver disease, as shown in mice with induced liver disease and in human livers biopsied from patients with liver fibrosis.
The cell-selective permeability of a retrievable microporous device encapsulating human therapeutic cells and implanted in the intraperitoneal space of mice provides long-term protection to the transplanted cells by dampening foreign-body responses and preventing the immune rejection of the graft.
Neuropathologies can be classified, on the basis of post-mortem histopathology and by using machine learning, into six transdiagnostic clusters associated with clinical phenotypes.
Gold nanoclusters stabilized by the milk metalloprotein α-lactalbumin and displaying multicolour and multimodal fluorescence aid the detection, resection and treatment of breast tumours in mice.
In the presence of recording instabilities, the performance of brain–computer interfaces can be robustly maintained by exploiting ‘hidden’ structures underlying neural activity.
The partial depletion of red blood cells via the administration of a low dose of anti-erythrocyte antibodies increases the circulation half-life of nanomedicines, as shown in rodent models of cancer.
A custom fidget spinner that uses centrifugal forces to concentrate bacterial pathogens in urine samples enables the rapid on-device colorimetric detection of urinary tract infections and the testing of the pathogen’s susceptibility to antibiotics.
An optofluidic chip incorporating a surface-enhanced Raman-scattering substrate rapidly detects picomolar concentrations of biomarkers of traumatic brain injury in finger-prick blood samples from patients.
The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces its presentation in uninflamed distal lymphoid organs, as shown in mice.
Biomarkers of health and disease in urine and stool can be longitudinally tracked with a ‘smart’ toilet incorporating biometric identification, pressure and motion sensors, urinalysis strips and a uroflowmeter.
The intravenous administration of a formulation of interleukin-12 that binds to collagen in established ‘immunologically cold’ murine tumours enhances interferon-γ production by T cells and causes tumour remission, especially when in combination with immune checkpoint blockade therapy.
The selection of double-bridged peptides via in vitro phage display yields constrained cyclic peptides optimized for high therapeutic specificity and for stability against gastrointestinal proteases.
The stabilization of co-administered insulin and pramlintide with cucurbit[7]uril-conjugated poly(ethylene glycol) in diabetic pigs enhances the overlap of their therapeutic windows.
