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The authors review how the blood–brain barrier, a regulatory interface that controls interactions between the blood and central nervous system, changes during healthy aging, and discuss how some of these changes may predispose to age-associated diseases.
Intermittent and periodic fasting are emerging as important interventions with the potential to extend longevity and healthspan. This Review discusses how they affect longevity and healthspan in model organisms and humans, their connection to major nutrient-sensing signaling pathways and the importance of refeeding.