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Aging can be conceptualized as the stochastic accumulation of damage and loss of resilience leading to organism demise. Resilience mechanisms that repair, recycle or replace damaged molecules and organelles are energy-demanding, therefore energy availability is essential to healthy aging. We propose that changes in mitochondrial and energy status regulate RNA splicing and that splicing is a resilience strategy that preserves energetic homeostasis with aging.
Plasma biomarkers pertaining to the underlying pathophysiology of Alzheimer’s disease have recently become available (for example, amyloid beta and phosphorylated tau). The utility of these markers poses a question for clinicians (now and in the future): are plasma biomarkers for Alzheimer’s disease are ready for clinical use at this time?
Nature Aging speaks with Paula Rochon, geriatrician and advocate for women’s healthy aging, about the specific health needs of older women and gendered ageism in health and social structures. Rochon reflects on her motivations and career, and shares her plans as the founding director of the Women’s Age Lab to help to improve health and social care to positively impact the health and well-being of older women.
It has been a year since Nature Aging published its first issue. We now reflect on this past year by highlighting some of the exciting content we have published. We also take this opportunity to share some of our experience in launching a journal during a pandemic and to extend our gratitude to the community.
