Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The external validity of the scientific literature has come into question, referred to as the “reproducibility crisis.” Pathology is likely no exception to this problem, and may be especially prone to false positives due to commonly used observational methodologies. The authors discuss possible sources of and solutions to non-reproducible pathology studies.